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Wang et al. J Transl Genet Genom 2023;7:126-40 Journal of Translational
DOI: 10.20517/jtgg.2023.07
Genetics and Genomics

Original Article Open Access

Epigenetic impact of long non-coding RNA
lnc-ADAM9 on extracellular matrix pathway in

preterm syndrome through down-regulation of
mRNA-ADAM9

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2
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Xiaohua Wang , Aiju Liu , Dongxia Hou , Xiaoyang Dong , Chu Chu , Weina Ju , Junhui Zhang , Yueqi
1
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Jia , Xiaoyan Yang , Yunpeng Ji , Tingting Wang , Elizabeth A. Bonney , Guixiang Wang , Nanbert Zhong 2
1
Inner Mongolia Maternity and Child Health Care Hospital, Hohhot, Inner Mongolia Autonomous Region 010060, China.
2
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.
3
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, VM 05404, USA.
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Authors contributed equally.
Correspondence to: Dr. Guixiang Wang, Inner Mongolia Maternity and Child Health Care Hospital, 18 North Second Ring Road,
Hohhot, Inner Mongolia Autonomous Region 010060, China. E-mail: fuyouwgx@sina.com; Dr. Nanbert Zhong, New York State
Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA. E-mail:
Nanbert.zhong@opwdd.ny.gov
How to cite this article: Wang X, Liu A, Hou D, Dong X, Chu C, Ju W, Zhang J, Jia Y, Yang X, Ji Y, Wang T, Bonney EA, Wang G,
Zhong N. Epigenetic impact of long non-coding RNA lnc-ADAM9 on extracellular matrix pathway in preterm syndrome through
down-regulation of mRNA-ADAM9. J Transl Genet Genom 2023;7:126-40. https://dx.doi.org/10.20517/jtgg.2023.07
Received: 6 Feb 2023 First Decision: 27 Mar 2023 Revised: 12 May 2023 Accepted: 5 Jun 2023 Published: 12 Jun 2023
Academic Editor: Sanjay Gupta Copy Editor: Fangling Lan Production Editor: Fangling Lan
Abstract
Aim: Evidence suggests that the risk of spontaneous preterm birth (sPTB) is the result of environmental exposure
interacting with genetic risk and is mediated by epigenetic modification. Long non-coding RNA (lncRNA)
comprises a large group of regulators of epigenetic modification that has recently become the focus of increased
investigation in reproductive science. Human placenta expresses many lncRNAs, and differential expression
profiles (DEPs) have identified several lncRNAs as associated with sPTB. However, little is known about lncRNA’s
role in the epigenetic modification of the genes potentially involved in sPTB. This study is to better understand the
epigenetic regulation of lncRNA on the development of sPTB.

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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