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Figure 1. MYC regulates cell growth in plasma cells and are dysregulated by translocation in plasma cell tumors [13,14] . During plasma cell
tumor development, Cdkn2a (p16) and Mndal (interferon inducible gene) expression is low and Mtor expression is increased [6,11,12,15]
Figure 2. BALB/c congenic strains of mice carrying two (p16 and Mtor) DBA/2 plasmacytoma resistance alleles are more resistant to
tumor formation than congenics carrying only one of the Pctr alleles
allelic defects tip the balance toward both uncontrolled cell growth and a lack of appropriately timed cell
death and removal from the cell cycle.
