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Biography
Marc Diederich earned his PhD in molecular pharmacology in 1994 from the University Henri Poincaré
Nancy 1, France. After training at the University of Cincinnati, USA, he focused his research on cancer and
leukemia cell signaling pathways and gene expression mechanisms triggered by natural compounds with
epigenetic-, anti-inflammatory- and cell death-inducing potential. He directs the Laboratory for molecular
and cellular biology of cancer (LBMCC) at Kirchberg Hospital in Luxemburg. He was appointed associate
Professor of Biochemistry at the College of Pharmacy of Seoul National University in 2012. In 2017, he was
tenured and promoted to full professor at SNU.

18. Co-expression of immune checkpoint genes at the cancer/antigen-presenting-cell side of
the immunological synapse

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1
Raya Leibowitz-Amit , Amir Herman , Adi Layani , Paula Dobosz , Yehezkel Sidi , Dror Avni
1 Oncology institute and cancer research center, Sheba medical center, Tel-Hashomer 52621, Israel.
2 Orthopedics department, Assuta medical center, Ashdod, Tel Aviv 69710, Israel.
Introduction: The interface between T lymphocytes and cancer cells or antigen-presenting cells (APC),
termed “the immunological synapse” (IS), comprises of both co-inhibitory and co-stimulatory checkpoint
proteins that modulate the signal transmitted to T lymphocytes, leading to either activation, anergy or
exhaustion. Monoclonal antibodies against checkpoint proteins (designated “checkpoint inhibitors”) have
anti-neoplastic activity in several malignancies, but not all cancers and not all patients within a given
cancer respond.

Methods: We analysed the tumor cancer genome atlas database for the expression of 15 checkpoint
mRNAs suggested from the literature to be expressed at the cancer/APC side of the IS in 28 tumor types.
The Spearman rho correlation co-efficient for the co-expression of each pair of checkpoint mRNAs was