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J Cancer Metastasis Treat 2019;5:31 I http://dx.doi.org/10.20517/2394-4722.2019.21 Page 10 of 36

with the standard diagnostic procedures like biomarkers, imaging techniques, and clinical stage
(multidisciplinary approach), new diagnostic algorithms based on multiparametric and multidisciplinary
approach for selected diagnoses are created and brings benefits both for the patient and the hospital.

Personalized medicine approach in University Hospital is closely connected with the education programme
realised at Faculty of Medicine in Pilsen Charles University.

Biography
Judita Kinkorová has completed his PhD from Academy of Science of the Czech Republic in Prague. She is
the associate professor, in the Department for immunochemistry University Hospital Pilsen and a manager
of biobank in University Hospital Pilsen. She has published more than 40 papers in reputed journals and
has been serving as an editorial board member of EPMA Journal.

13. TM4SF5-mediated hepatic carcinogenesis

Jung Weon Lee

Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Korea.

Diverse functions of cancer cells including proliferation, migration and invasion critically and greatly
depend on extracellular environment during their survival and metastasis. The environment consists of
extracellular matrix proteins, neighboring cells, and soluble factors, including of cytokines, chemokines,
and growth factors. Efficient dissemination of a cancer cell from a primary tumor mass and invasion
through the environment can result in a successful metastasis. Therefore, identification of biological cancer
marker(s) playing roles in diverse cancerous functions would be beneficial for clinical and therapeutic
purposes, and can be performed in 2D flat, 3D cell and tissue cultures, and animal models. Transmembrane
4 L six family member 5 (TM4SF5) is a transmembrane glycoprotein of the transmembrane 4 L six family, a
branch of the tetraspan(in) family, highly expressed in many types of cancers including hepatic cancer, and
shown to cause epithelial-mesenchymal transition. TM4SF5 in hepatocytes is induced by TGFb1-mediated
Smad and EGFR activation and involved in liver fibrosis. Transgenic animal showed that overexpression of
TM4SF5 in liver caused inflammatory, fatty, and fibrotic phenotypes, indicating that TM4SF5 expression
following actions by TGFb1 prevalent in chronic liver injury situation may lead to playing regulatory
roles in functions for different metabolic pathways. Further, disease-prone TM4SF5 transgenic mice
showed enhanced expressions of CD34, HIF1-a, AFU, and AFP in the livers. A small calchone compound,
TSAHC and chimeric anti-TM4SF5 antibody could successfully block the TM4SF5-mediated regulation of
metabolic activities, fibrosis, and xenograft tumor formation.

Biography
Dr. Jung Weon Lee is a Professor at Dept. of Pharmacy, Seoul National University (SNU), Korea. He got
Ph.D. in Pharmacology, University of North Carolina at Chapel Hill, NC, USA. He had a postdoc period at
Memorial Sloan-Kettering Cancer Center, NY, USA. In 2001, He came back to Korea, and in 2009 moved to
Dept. of Pharmacy, SNU. His researches focuse on how cellular functions occur at the molecular levels. His
researches focuses on the roles of a tetraspanin, TM4SF5, in metabolic dysorders, fibrosis, tumorigenesis
and metastasis, and on the anti-TM4SF5 reagents to block TM4SF5-mediated diseases (Lab homepage:
http://www.snupharm.ac.kr/jwl/).