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Figure 1: Most common types of brain tumors [6-8]

occur in people between 65 and 79 years of age. [5] grade III brain tumors are managed similarly.
This review provides an overview of the management of primary Any intracranial tumor, regardless of the degree of malignancy,
brain tumors, especially glioblastoma multiforme. The huge can potentially invade or displace critical brain areas, resulting in
surge in the development of novel strategies for management neurologic compromises. The most common complications
[12]
of primary brain tumors in the past 5 years will be demonstrated are seizures, peritumoral edema, venous thromboembolism,
in this review article via recent published patents. Table 1 fatigue, and cognitive dysfunction. [11-13]
enumerates patents on brain drug delivery and treatment of brain
tumors between 2010 and 2015 [supplement material Table 1]. GBM, is usually described in two different clinical forms,
[14]
This part of the review will focus on recent patents and studies primary and secondary. Primary GBM is the most common
using nanoparticles and bioconjugates in brain tumor treatment form (about 95%); it typically arises de novo, within 3-6 months,
and diagnosis.

TYPES OF BRAIN TUMORS

Primary brain tumors originate within brain tissue. They are
classified according to the type of originating tissue [Figure 1].
The most common primary brain tumors are gliomas, pituitary
adenomas, and vestibular and primitive neuroectodermal
tumors. Gliomas are tumors that begin in the glial tissue.
[6,7]
Gliomas include glioblastomas, astrocytomas, schwannomas,
oligodendrogliomas, and others.
[8]
Figure 2: Diagram illustrating the difference between BBB and BBTB.
The most common malignant brain tumor is glioblastoma BBB: blood brain barrier; BBTB: blood brain tumor barrier
multiforme (GBM, 81% of malignant CNS tumors), which is
usually associated with poor prognosis. [9-11] GBM is classified in older patients. On the other hand, secondary GBM arises
as a subtype of astrocytoma. GBM is classified as grade IV/V from prior low-grade astrocytomas over 10-15 years in younger
according to the WHO. With regard to treatment, GBM and patients. Both types respond similarly to treatment. [13]
[13]
[11]
Journal of Cancer Metastasis and Treatment ¦ Volume 2 ¦ March 15, 2016 ¦ 113