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Rabadi et al. J Cancer Metastasis Treat 2022;8:24  https://dx.doi.org/10.20517/2394-4722.2022.06  Page 11 of 14

               Financial support and sponsorship
               Research was supported by NIH grants R01AR070760 and R01CA214062 (Randolph J. Noelle).


               Conflicts of interest
               Randolph J. Noelle is an inventor on patent applications (10035857, 9631018, 9217035, 8501915, 8465740,
               8236304, and 8231872) submitted by Dartmouth College, and patent applications (9890215 and 9381244)
               submitted by Kings College London and Dartmouth College and a co-founder of ImmuNext, a company
               involved in the development of VISTA-related assets. These applications cover the use of VISTA targeting
               for modulation of the immune response. Dina Rabadi is a past employee of ImmuNext.


               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2022.

               REFERENCES
               1.       Weir HK, Thompson TD, Stewart SL, White MC. Cancer incidence projections in the united states between 2015 and 2050. Prev
                    Chronic Dis 2021;18:E59.  DOI  PubMed  PMC
               2.       Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A. Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell
                    2017;168:707-23.  DOI  PubMed  PMC
               3.       Ribas A, Wolchok JD. Cancer immunotherapy using checkpoint blockade. Science 2018;359:1350-5.  DOI  PubMed  PMC
               4.       Wei SC, Duffy CR, Allison JP. Fundamental mechanisms of immune checkpoint blockade therapy. Cancer Discov 2018;8:1069-86.
                    DOI  PubMed
               5.       Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol 2015;15:486-99.  DOI  PubMed
                    PMC
               6.       Thommen DS, Schreiner J, Müller P, et al. Progression of lung cancer is associated with increased dysfunction of t cells defined by
                    coexpression of multiple inhibitory receptors. Cancer Immunol Res 2015;3:1344-55.  DOI  PubMed
               7.       Xia A, Zhang Y, Xu J, Yin T, Lu XJ. T Cell dysfunction in cancer immunity and immunotherapy. Front Immunol 2019;10:1719.
                    DOI  PubMed  PMC
               8.       Wolchok JD, Chiarion-Sileni V, Gonzalez R, et al. Overall survival with combined nivolumab and ipilimumab in advanced
                    melanoma. N Engl J Med 2017;377:1345-56.  DOI  PubMed  PMC
               9.       Le Mercier I, Chen W, Lines JL, et al. VISTA regulates the development of protective antitumor immunity.  Cancer Res
                    2014;74:1933-44.  DOI  PubMed  PMC
               10.       Kakavand H, Jackett LA, Menzies AM, et al. Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance
                    to anti-PD-1 therapy in metastatic melanoma patients. Mod Pathol 2017;30:1666-76.  DOI  PubMed
               11.       Gao J, Ward JF, Pettaway CA, et al. VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients
                    with prostate cancer. Nat Med 2017;23:551-5.  DOI  PubMed  PMC
               12.       Broughton TWK, ElTanbouly MA, Schaafsma E, et al. Defining the signature of VISTA on myeloid cell chemokine responsiveness.
                    Front Immunol 2019;10:2641.  DOI  PubMed  PMC
               13.       Flies DB, Wang S, Xu H, Chen L. Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents
                    graft-versus-host disease in mouse models. J Immunol 2011;187:1537-41.  DOI  PubMed  PMC
               14.       ElTanbouly MA, Zhao Y, Nowak E, et al. VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
                    Science 2020;367:eaay0524.  DOI  PubMed  PMC
               15.       Wang L, Rubinstein R, Lines JL, et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J Exp
                    Med 2011;208:577-92.  DOI  PubMed  PMC
               16.       Mehta N, Maddineni S, Mathews II, Sperberg AP, Huang PS, Cochran JR. Structure and functional binding epitope of v-domain Ig
                    suppressor of t-cell activation (VISTA). Cell Rep 2019;28:2509-16.e5.  DOI
               17.       Slater BT, Han X, Chen L, Xiong Y. Structural insight into T cell coinhibition by PD-1H (VISTA). Proc Natl Acad Sci USA
                    2020;117:1648-57.  DOI  PubMed  PMC
               18.       Yum JI, Hong YK. Terminating cancer by blocking VISTA as a novel immunotherapy: hasta la vista, baby. Front Oncol
                    2021;11:658488.  DOI  PubMed  PMC
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