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Figure 1. Immune cell inference is associated with patient prognosis. KM plots showing the association between high and low levels of
(A) naïve B cells; (B) memory B cells; (C) CD8+ T cells; (D) NK cells; (E) CD4+ T cells; and (F) Monocytes in the Oberthuer dataset.
LR-p: P-value calculated by Log-rank tests; HR: hazard ratio from univariate Coxph regression models; Cox-p: P-value calculated by
univariate Coxph regression models.

Figure 2. Naïve B cells consistently associated with overall and recurrence-free survival. (A) KM plots showing the association between
high and low levels of naïve B cell infiltration and overall survival in the SEQC, Rajbhandari, ICGC (TARGET), Westerman and Berwanger
datasets (datasets ordered based on sample size). (B) KM plots showing the association between high and low levels of naïve B cell
infiltration and recurrence-free survival in the Oberthuer, SEQC, and Rajbhandari datasets (datasets ordered based on sample size).
LR-p: P-value calculated by Log-rank tests; HR: hazard ratio from univariate Coxph regression models; Cox-p: P-value calculated by
univariate Coxph regression models.

is associated with prognosis in neuroblastoma irrespective of clinical variables and MYCN amplification
status.