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oxidative phosphorylation, even under normoxic Financial support and sponsorship
conditions. Aberrant metabolism in tumor cells can
generate the abnormally high levels of reactive oxygen Nil.
species (ROS), which induce senescence or apoptosis. Confl icts of interest
To counter such oxidative stress, cancer cells exert tight There are no confl icts of interest.
regulation of ROS and antioxidants in such a way that
the cell survives and the levels of ROS are reduced to References
moderate levels. Sawayama et al. review the molecular
[2]
mechanism of cancer metabolism, and demonstrate 1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J,
possible therapeutic strategies targeting metabolism. Jemal A. Global cancer statistics, 2012. CA Cancer J Clin
2015;65:87-108.
Molecular targeted drugs block the pathways 2. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell
specifi cally involved in tumorigenesis and the metabolism. Nat Rev Cancer 2011;11:85-95.
progression of cancers. Several targeted drugs have
already been introduced into cancer treatment, and This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows
vascular endothelial growth factor and epithelial others to remix, tweak, and build upon the work non-commercially, as long as
growth factor receptor are two major targets in the the author is credited and the new creations are licensed under the identical
terms.
treatment for colorectal cancer. An antibody targets
HER-2 has become a standard choice for gastric cancer For reprints contact: reprints@medknow.com
with HER-2 overexpression/amplifi cation. Currently, Access this article online
many candidate-targeted agents are under clinical or
preclinical study. Eto et al. summarize trends in the Quick Response Code: Website:
clinical use of targeted drugs for GI cancers. www.jcmtjournal.com
All of nine, fi rst authors of review articles in this issue are
young researchers who had started their research career at DOI:
the Department of Gastroenterological Surgery, Graduate 10.4103/2394-4722.166973
School of Medical Sciences, Kumamoto University.
I would like to express my sincere appreciation to How to cite this article: Watanabe M. Introduction to Volume 1 Issue 3
Prof. Hideo Baba and all members in his department for of Journal of Cancer Metastasis and Treatment. J Cancer Metastasis
their guidance and support for this project. I am very Treat 2015;1:111-2.
happy if you enjoyed this special issue. Received: 17-08-2015; Accepted: 31-08-2015.

112 Journal of Cancer Metastasis and Treatment ¦ Volume 1 ¦ Issue 3 ¦ October 15, 2015 ¦