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Page 8 of 12 Baker et al. J Cancer Metastasis Treat 2020;6:24 I http://dx.doi.org/10.20517/2394-4722.2020.36

Figure 2. Percentages of individual risk factors identified at enrollment across all patients, stratified by age at baseline. Note: except for
body mass index (BMI) and high-sensitivity C-reactive protein (hsCRP), these are distinct from, and derived using different data than,
the baseline laboratory measurements

elevations in oncology settings. Going forward, patients will have received a coronary artery calcium score
to monitor for coronary artery calcification in lieu of chest X-ray alone. Surprisingly, in our series, three
patients aged 18-24 were found to have visible coronary artery calcifications on routine chest computed
tomography as part of their malignancy surveillance. We have learned from cardiologists that CAD is at
least in part an inflammatory process. We routinely measure hsCRP and more than half of our patients
had maintained an elevation of hsCRP; Isolated elevations are most often the consequence of infection.
[32]
Experimental evidence demonstrates inflammatory changes soon after doxorubicin administration .
All patients with abnormal renal function are cautioned about the use of contrast agents for imaging and
ibuprofen for pain management.

All patients are given a survivorship care plan and instructed to share their care plan with their other
providers. Staffed by a medical oncologist and nurse practitioner, considerable time is dedicated to