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Page 12 of 16 Yeger et al. J Cancer Metastasis Treat 2020;6:26 I http://dx.doi.org/10.20517/2394-4722.2020.61

and significantly retarding malignant progression of cancer while Musci et al. [115] voiced the same message
for maintenance of skeletal muscle and healthspan extension via exercise induced balanced mitohormesis.
Given that ITCs could positively influence mitochondrial functions, bolstering mitohormesis, and that
cancer cells and normal cells differ sufficiently in mitochondrial functions, ITCs and other phytochemicals
could show the desirable selectivity.

Figure 1 schema presents a common sense strategy illustrating that leading a physically active lifestyle and
consuming a phytochemical rich MedDiet, where ITCs figure prominently, may be the best defense against
cancer and concomitantly for maintaining the health of all organ systems.

DECLARATIONS
Authors’ contributions
Contributed equally to the literature search and the writing of this manuscript: Yeger H, Mokhtari RB
First developed the concept and the Figure Schema: Yeger H

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

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