Page 16 - Read Online

Page 12 of 14 Santoni et al. J Cancer Metastasis Treat 2020;6:22 I http://dx.doi.org/10.20517/2394-4722.2020.49

9. Bertoli C, Skotheim JM, De Bruin RAM. Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol
2013;14:518-28.
10. Jung YS, Qian Y, Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal
2010;22:1003-12.
11. Mullan PB, Quinn JE, Harkin DP. The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene 2006;25:5854-63.
12. MengXM, Chung ACK, Lan HY. Role of the TGF-β/BMP-7/Smad pathways in renal diseases. Clin Sci 2013;124:234-54.
13. Lee EW, Lee MS, Camus S, Ghim J, Yang MR, et al. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle
arrest and apoptosis. EMBO J 2009;28:2100-13.
14. Xu H, Wang Z, Jin S, Hao H, Zheng L, et al. Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression.
BiochemBiophys Res Commun 2014;446:235-40.
15. Hydbring P, Malumbres M, Sicinski P. Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat Rev Mol Cell
Biol 2016;17:280-92.
16. Wu S, CetinKaya C, Munoz-Alonso MJ, Von Der Lehr N, Bahram F, et al. Myc represses differentiation-induced p21/Cip1 expression via
Miz-1-dependent interaction with the p21 core promoter. Oncogen2003;22:351-60.
17. Choi W Il, Kim MY, Jeon BN, Koh DI, Yun CO, et al. Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-
dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression. J Biol Chem 2014;289:18625-40.
18. Zeng PY, Berger SL. LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. Cancer Res
2006;66:10701-8.
19. Lai D, Chen Y, Wang F, Jiang L, Wei C. LKB1 controls the pluripotent state of human embryonic stem cells. Cell Reprogram
2018;14:164-70.
20. Koutsodontis G, Tentes I, Papakosta P, Moustakas A, Kardassis D. Sp1 plays a critical role in the transcriptional activation of the human
cyclin-dependent kinase inhibitor p21WAF1/Cip1 gene by the p53 tumor suppressor protein. J Biol Chem 2001;276:29116-25.
21. Kim HS, Heo JI, Park SH, Shin JY, Kang HJ, et al. Transcriptional activation of p21 WAF1/CIP1 is mediated by increased DNA
binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic
fibroblasts. Mol Biol Rep 2014;41:2397-408.
22. Karimian A, Ahmadi Y, Yousefi B. Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage.
DNA Repair (Amst) 2016;42:63-71.
23. Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, et al. Temozolomide induces senescence and repression of DNA repair pathways in
glioblastoma cells via activation of ATR-CHK1, p21, and NF-κB. Cancer Res 2019;79:99-113.
24. Chen JF, Luo X, Xiang LS, Li HT, Zha L, et al. EZH2 promotes colorectal cancer stem-like cell expansion by activating p21/Cip1-Wnt/
catenin signaling. Oncotarget 2016;7:41540-58.
25. Wen Y, Cai J, Hou Y, Huang Z, Wang Z. Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target. Oncotarget
2017;8:37974-90.
26. Fan TY, Wang H, Xiang P, Liu YW, Li HZ, et al. Inhibition of EZH2 reverses chemotherapeutic drug TMZ chemosensitivity in
Glioblastoma. Int J Clin ExpPathol 2014;7:6662-70.
27. Xie Q, Wu Q, Mack SC, Yang K, Kim L, et al. CDC20 maintains tumor initiating cells. Oncotarget 2015;6:13241-54.
28. Morris-Hanon O, Furmento VA, Rodríguez-Varela MS, Mucci S, Fernandez-Espinosa DD, et al. The cell cycle inhibitors p21/Cip1 and
p27Kip1 control proliferation but enhance DNA damage resistance of glioma stem cells. Neoplasia 2017;19:519-29.
29. Glaser T, Wagenknecht B, Weller M. Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis
in human malignant glioma cells. Oncogene 2001;20:4757-67.
30. Head RJ, Fay MF, Cosgrove L, Fung K, Rundle-Thiele D, et al. Persistence of DNA adducts, hypermutation and acquisition of cellular
resistance to alkylating agents in glioblastoma. Cancer Biol Ther 2017;18:917-26.
31. Happold C, Roth P, Wick W, Schmidt N, Florea AM, et al. Distinct molecular mechanisms of acquired resistance to temozolomide in
glioblastoma cells. J Neurochem 2012;122:444-55.
32. Mostofa A, Punganuru SR, Madala HR, Srivenugopal KS. S-phase specific downregulation of human O6-methylguanine DNA
methyltransferase (MGMT) and its serendipitous interactions with PCNA and p21cip1 proteins in glioma cells. Neoplasia 2018;20:305-23.
33. Acunzo M, Romanoo G, Wernicke D, Croce CM. MicroRNA and cancer-a brief overview. Adv Biol Regul 2015;57:1-9.
34. Gabriely G, Yi M, Narayan RS, Niers JM, Wurdinger T, et al. Human glioma growth is controlled by microRNA-10b. Cancer Res
2011;71:3563-72.
35. Teplyuk NM, Uhlmann EJ, Wong AH, Karmali P, Basu M, et al. MicroRNA-10b inhibition reduces E2F1-mediated transcription and
miR-15/16 activity in glioblastoma. Oncotarget 2015;6:3770-83.
36. El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Genome editing reveals glioblastoma addiction to microRNA-10b. Mol Ther
2017;25:368-78.
37. Ernst A, Campos B, Meier J, Devens F, Liesenberg F, et al. De-repression of CTGF via the miR-17-92 cluster upon differentiation of
human glioblastoma spheroid cultures. Oncogene 2010;29:3411-22.
38. Wu ZB, Cai L, Lin SJ, Lu JL, Yao Y, et al. The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas. Brain
Res 2013;1529:16-25.
39. Zhong Q, Wang T, Lu P, Zhang R, Zou J, et al. miR-193b promotes cell proliferation by targeting Smad3 in human glioma. J Neurosci
Res 2014;92:619-26.
40. Chen R, Liu H, Cheng Q, Jiang B, Peng R, et al. MicroRNA-93 promotes the malignant phenotypes of human glioma cells and induces