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Table 1.Liquid biopsy biospecimen and molecules in endometrial cancer
Biospecimen Biomolecule Biomarker Suggested for Not assayed in EC Sample analyzed Ref.
Bloodn CTCs Protein Diagnosis 10 [81]
mRNA 62 [24]
24 [28]
92 [29]
24 [30]
311 [31]
DTCs DNA Diagnosis 34 [22]
401 [24]
13 [27]
24 [28]
Single CTC x [30]
Ct/cfDNA Mutation Diagnosis 44 [37]
109 [50]
48 [51]
5 [52]
Integrity/ Biomarkers 60 [53]
amount 53 [55]
CNV 53 [54]
mtDNA Presence 59 [56]
miRNA Expression Diagnosis/ 3580 [24]
prognosis 44 [63]
32 [64]
77 [66]
42 [67]
267 [72]
93 [73]
3568 [75]
Methylation Biomarkers 45 [76]
mRNA Expression (hTER) Biomarkers 56 [79]
Protein Expression (leptin) Biomarkers 10 [77]
HE4 Biomarkers 5 [78]
circRNA x [101]
lncRNA x
snRNA x
snoRNA x
piRNA x
Extracellular vesicle DNA x
miRNA x
mRNA x
circRNA Biomarkers 3 [84]
Protein Biomarkers 10 [81]
Platelet x [85]
miRNA x
mRNA x
circRNA x
Protein x
lncRNA x
Urine Ct/cfDNA x
miRNA Biomarkers 20 [24,88]
mRNA x
Protein x
circRNA x
Extracellular vesicle DNA x
miRNA x
mRNA x
circRNA x
Protein x
