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REFERENCES
1. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, et al. Glioblastoma microvesicles transport RNA and proteins that promote
tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10:1470-6.
2. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism
of genetic exchange between cells. Nat Cell Biol 2007;9:654-9.
3. Iorio MV, Croce CM. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO
Mol Med 2012;4:143-59.
4. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, et al. Large Differences in small RNA Composition between human biofluids.
Cell Rep 2018;25:1346-58.
5. Yeri A, Courtright A, Reiman R, Carlson E, Beecroft T, et al. Total extracellular small RNA profiles from plasma, saliva, and urine of
healthy subjects. Sci Rep 2017;7:44061.
6. Saugstad JA, Lusardi TA, Van Keuren-Jensen KR, Phillips JI, Lind B, et al. Analysis of extracellular RNA in cerebrospinal fluid. J
Extracell Vesicles 2017;6:1317577.
7. Lasser C, Alikhani VS, Ekstrom K, Eldh M, Paredes PT, et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by
macrophages. J Transl Med 2011;9:9.
8. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, et al. Diverse human extracellular RNAs are widely detected in human plasma.
Nat Commun 2016;7:11106.
9. Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, Gonzalez S, Sanchez-Cabo F, et al. Unidirectional transfer of microRNA-
loaded exosomes from t cells to antigen-presenting cells. Nat Commun 2011;2:282.
10. Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, et al. Functional delivery of viral miRNAs via
exosomes. Proc Natl Acad Sci U S A 2010;107:6328-33.
11. Balaj L, Lessard R, Dai L, Cho YJ, Pomeroy SL, et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene
sequences. Nat Commun 2011;2:180.
12. Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu
Rev Cell Dev Biol 2014;30:255-89.
13. van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol 2018;19:213-28.
14. Chen X, Ba Y, Ma L, Cai X, Yin Y, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer
and other diseases. Cell Res 2008;18:997-1006.
15. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, et al. Circulating microRNAs as stable blood-based markers for cancer
detection. Proc Natl Acad Sci U S A 2008;105:10513-8.
16. Tabet F, Vickers KC, Cuesta Torres LF, Wiese CB, Shoucri BM, et al. HDL-transferred microRNA-223 regulates ICAM-1 expression in
endothelial cells. Nat Commun 2014;5:3292.
17. Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient
cells by high-density lipoproteins. Nat Cell Biol 2011;13:423-33.
18. Quinn JF, Patel T, Wong D, Das S, Freedman JE, et al. Extracellular RNAs: development as biomarkers of human disease. J Extracell
Vesicles 2015;4:27495.
19. Lombo TB, Ganguly A, Tagle DA. Diagnostic potential of extracellular RNA from biofluids. Expert Rev Mol Diagn 2016;16:1135-8.
20. Siravegna G, Marsoni S, Siena S, Bardelli A. Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol
2017;14:531-48.
21. Heitzer E, Haque IS, Roberts CES, Speicher MR. Current and future perspectives of liquid biopsies in genomics-driven oncology. Nat
Rev Genet 2019;20:71-88.