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Happel et al. J Cancer Metastasis Treat 2020;6:32 I http://dx.doi.org/10.20517/2394-4722.2020.71 Page 11 of 18

A Funding type Award count
4
Career Development
Common Fund 8
Conference Support 8
Intramural 15
Research Project 87
Research Training 6
SBIR 10
Grand Total 138

B

Figure 4. NIH supported research focused on exRNA and exosomes as cancer biomarkers. An advanced text search for (“extracellular
RNA” OR exosome OR exRNA OR oncosome) AND cancer AND biomarker was performed on NIH RePORTER (https://projectreporter.
nih.gov/reporter.cfm) on 9 May 2020. The text search was limited to project abstracts, project title, and project terms, and was focused
on new awards only (excluding subprojects), funded by any NIH Institute or Center from 2010-2020. The search returned 138 projects,
which are summarized in Figures 4A and B. A: NIH funded projects were grouped by general funding types; B: NIH funded projects were
grouped by general cancer type and the number of projects focused on each cancer type are shown. Projects that did not specify cancer
type were grouped together as non-specific cancer

A large majority (85 out of 138) of the NIH funded projects that focused on exRNA and exosomes as
biomarkers in cancer were not directed toward any specific cancer type [Figure 4B]. Furthermore, the 53
remaining projects were spread across 15 different types of cancer.