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Table 2. ICM-related inflammatory reactions/autoimmune conditions and their associated symptoms
Organ system Inflammatory reaction/condition Symptoms (n = 142 unique symptoms)
(n = 11) (n = 75)
Cutaneous Rash; pruritus; psoriasis; pitted or Rash, rash-pain, rash-blister, rash-itch, skin-itch, skin-dry/cracked, skin-
ridged nails; vitiligo; Steven’s Johnson’s peeling, skin-burning, skin-thickened, nails-pitted, nails-ridged, skin-
syndrome; Lyell’s syndrome (toxic depigmentation, fever, skin-pain, mouth-blisters, mouth-pain, malaise, hair
epidermal necrosis); alopecia; Sweet loss
syndrome
Gastrointestinal Colitis; pancreatitis; stomatitis/ Diarrhea, abdominal-pain, weight-loss, fever, nausea, vomiting, blood in stool,
oral mucositis; lichenoid mucositis; fatigue, pain radiating to the back, shortness of breath, mouth-sores, mouth-
esophagitis; gastritis; celiac disease; pain, taste changes, swallowing-difficulty, swallowing-pain, chest-pain
reflux; cholangitis; intestinal (burning), heartburn, abdominal-fullness, appetite-loss, abdominal-bloating,
perforation; cholecystitis; gastric regurgitation, skin-itchy, eyes-itchy, mouth-dry, urinary-infrequency, thirst-
hemorrhage; paralytic bowel increased, abdominal-distention, sensitivity-food, vomiting-blood, rectal
obstruction bleeding, constipation
Hepatic Hepatitis; acute liver failure Fatigue, abdominal-pain, joint-pain, jaundice, abdominal-swelling, nausea,
vomiting, malaise, disorientation, confusion, sleepiness, dark urine
Renal Interstitial nephritis; nephrotic Weight-gain, edema, fever, urine-blood, nausea, vomiting, urinary-frequency,
syndrome; acute kidney injury urinary-infrequency, urine-foamy, appetite-loss, shortness of breath, fatigue,
confusion, weakness
Lung Pneumonitis; pleuritis; sarcoidosis/ Shortness of breath, cough, fatigue, appetite-loss, weight-loss, chest-pain,
sarcoid-like granulomatosis fever, joint-pain, joint-swelling, lymph swelling, rash, vision-blurred, eyes-pain
Endocrine Hypophysitis/hypopituitarism; Headache, fatigue, muscle-weakness, nausea, appetite-loss, weight-loss,
primary hyperthyroidism; vision-blurred, intolerance-cold, intolerance-heat, constipation, skin-dry,
primary adrenal insufficiency; weight-gain, muscle-pain/ache, joint-pain, joint-stiffness, joint-swelling,
hyperglycemia/autoimmune diabetes; depression, memory impairment, abdominal-pain, nausea, vomiting, diarrhea,
diabetic ketoacidosis; primary lightheadedness/dizziness, thirst-increased, urinary-frequency, appetite-
hypoparathyroidism; thyrotoxicosis/ increase, irritability, anxiety, palpitations, bone pain, sweating-excessive,
hyperthyroidism; Cushing’s syndrome bowel-frequent movements, bruising-easy, face-reddening, skin-thinning,
moon face appearance, mood changes
Musculoskeletal Myalgia; arthralgia; inflammatory Muscle-pain/ache, joint-pain, joint-stiffness, joint-swelling, joint-decreased
arthritis; dermatomyositis; myopathy; range of motion, skin- swelling, back pain, skin-rash (violet or red), skin-itch,
inflammatory myositis; polymyalgia skin-pain, sensitivity-touch, muscle-weakness, muscle-soreness, fatigue,
rheumatica; Sicca-Sjogren’s like swallowing-difficulty, shortness of breath, joint-ache, groin-pain, fever (low-
syndrome; sarcoidosis-like reactions grade), malaise, depression, appetite-loss, weight-loss, mouth-dry, face-pain,
tooth-decay, mouth-pain, eyes-dry, taste changes, shortness of breath, lymph
swelling, cough, wheezing, eyes-pain, eyes-redness, functional interference/
eat and sleep interference
Nervous Neuropathy; Guillain-Barre syndrome; Numbness, pain, pain-burning (nerve), muscle-weakness, coordination-
myelopathy; transverse myelitis; difficulty, paralysis, intolerance-heat, sweating-excessive, sweating-
meningitis; encephalitis; myasthenic decreased ability, dizziness/lightheadedness, tingling, numbness, balance-
syndrome/myasthenia gravis; facial problems, urine-loss of control, bowel-loss of control, sensitivity-touch, fever,
nerve palsy headache, stiff neck, nausea, vomiting, confusion, sleepiness, sensitivity-light,
muscle-pain/ache, joint-ache, fatigue, eyelid-drooping, muscle-weakness
(that is better with rest), vision-double, swallowing-difficulty, voice changes,
drooling, facial droop, jaw pain, taste changes
Hematologic Hemolytic anemia; aplastic anemia; Fever, weakness, dizziness, confusion, urine-blood, paleness, jaundice,
idiopathic thrombocytopenia purpura; palpitations, bruising-easy, bleeding-pinpoint (petechiae), bleeding-easy,
pancytopenia; hemophilia bleeding-gum, bleeding-nose, blood in stool, fatigue, shortness of breath,
joint-pain, joint-swelling, lightheadedness/dizziness
Cardiovascular Myocarditis; vasculitis/temporal Chest pain, fatigue, shortness of breath, edema, palpitations, fever, headache,
arteritis; interstitial lung disease; weight-loss, muscle-pain/ache, muscle-pain, sweating-nocturnal, rash,
pericarditis; cardiomyopathy; heart numbness, weakness, tingling, cough-dry, shortness of breath-lying down.
failure; pericardial effusion; Raynaud’s cough-lying down, abdominal-swelling, chest-pressure, lightheadedness/
phenomenon dizziness, wheezing, weight-gain, urinary frequency-nocturnal, chest-fullness,
fingers-cold, toes-cold, functional impairment such as reduced exercise
intolerance
Ocular Uveitis/choroiditis; conjunctivitis; Eyes-redness, eyes-pain, sensitivity-light, vision-blurred, vision-floaters,
scleritis; episcleritis; blepharitis; vision-decreased, eyes-itchy, eyes-gritty, eyes-crusty, eyes-watery, eyes-pain
retinitis; orbital myositis with eye movement, eyelids-itchy, eyelids-red/swollen, vision-loss, vision-
impaired color vision, vision-double, eyelid-drooping
ICM: immune checkpoint modulators

face pain, stiff neck, numbness, tingling, burning pain, back pain, paralysis, sweating-decreased ability,
muscle-weakness, sleepiness, drooling, double vision, light sensitivity, jaw pain, voice changes, swallowing
difficulty/choking, bladder control, and bowel control); musculoskeletal (joint pain, joint stiffness, joint
swelling, muscle pain/soreness, decreased range of motion, functional interference, and bone pain); eyes (eye