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Webster et al. J Cancer Metastasis Treat 2020;6:8 Journal of Cancer
DOI: 10.20517/2394-4722.2019.38 Metastasis and Treatment

Original Article Open Access

Development of a Functional Assessment of
Chronic Illness Therapy item library and primary

symptom list for the assessment of patient-reported
adverse events associated with immune checkpoint

modulators

Kimberly A. Webster , Mary L. O’Connor , Aaron R. Hansen , Sheetal Kircher , Heather S. L. Jim , Adam
3
4
1
2
1
P. Dicker , Monika Janda , Kari Ala-leppilampi , Clifton O. Bingham III , Josephine Feliciano , Norah Lynn
6
5
7
8
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Henry , Laurie E. Steffen McLouth , David Cella 1
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1 Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
2 Princess Margaret Cancer Center, University Health Network, Toronto M5G 1Z5, Canada.
3 Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
4 Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USA.
5 Department of Radiation Oncology, Sidney Kimmel Medical College and Cancer Center at Thomas Jefferson University,
Philadelphia, PA 19107, USA.
6 Centre for Health Services Research, The University of Queensland, QLD 4102, Australia.
7 Applied Health Research Centre, Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto M5B 1W8, Canada.
8 Divisions of Rheumatology and Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA.
9 Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
10 University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
11 Department of Behavioral Science, Center for Health Equity Transformation and Markey Cancer Center, University of Kentucky
College of Medicine, Lexington, KY 40536, USA.
Correspondence to: Kimberly A. Webster, Department of Medical Social Sciences, 625 N. Michigan Avenue, Suite 2700,
Chicago, IL 60611, USA. E-mail: k-webster@northwestern.edu
How to cite this article: Webster KA, O’Connor ML, Hansen AR, Kircher S, Jim HSL, Dicker AP, Janda M, Ala-leppilampi K,
Bingham CO III, Feliciano J, Henry NL, Steffen McLouth LE, Cella D. Development of a Functional Assessment of Chronic Illness
Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune
checkpoint modulators. J Cancer Metastasis Treat 2020;6:8. http://dx.doi.org/10.20517/2394-4722.2019.38
Received: 7 Oct 2019 Accepted: 24 Feb 2020 Published: 13 Mar 2020
Science Editor: Pravin D. Potdar Copy Editor: Jing-Wen Zhang Production Editor: Jing Yu

Abstract

Aim: To develop a comprehensive item library of patient-reported, immunotherapy-related adverse events (irAEs)
that draws from and expands on the Functional Assessment of Chronic Illness Therapy (FACIT) Measurement
System.

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
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