Page 42 - Read Online
P. 42
Sun et al. J Cancer Metastasis Treat 2019;5:80 I http://dx.doi.org/10.20517/2394-4722.2019.29 Page 5 of 7
Figure 1. Activation of NK cell using anti-LLT1 monoclonal antibody. (Left) Prostate and triple-negative breast cancer cells express LLT1
which can bind to NKRP1A on NK cells leading to inhibition of NK cell function. (Right) However, in the presence of anti-LLT1 antibodies,
NK cells can be activated via two mechanisms: (1) blocking of LLT1 prevents inhibitory signal transmission; and (2) activation when NK
cell receptor CD16 binds to anti-LLT1 antibody bound to LLT1 on cancer cells. Image created using BioRender (www.BioRender.com). NK:
natural killer; LLT1: lectin-like transcript 1; mAb: monoclonal antibody
DECLARATIONS
Authors’ contributions
Designed and wrote manuscripts: Sun Y, Malaer JD, Mathew PA
Revised manuscript: Malaer JD, Mathew PA
Built figures: Malaer JD
Availability of data and materials
Not applicable.
Financial support and sponsorship
T32 AG020494-16A1.
Conflicts of interest
All authors declared that there are no conflicts of interest.
Ethical approval and consent to participate
Not applicable.
