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Figure 1. A schematic representation of the interplay between diet and metabolism in determining the fatty acid profile of adipose tissue.
The consequences of adipose tissue dysfunction in the pathogenesis of obesity-related morbidities including cancer are depicted

especially the clinical trials, carried out until now provide often contrasting results. This should drive to
implement new researches specifically addressed to clarify the relationship among the various molecular
pathways involved in FA metabolism and inflammation establishment. The improvement of knowledge
on the real role that dietary habits play in modulating key metabolic processes, will allow to provide
personalized nutritional advices that take in account the inter-individual differences, including those
gender-related, in the response to diet.

DECLARATIONS
Authors’ contributions
Made substantial contributions to conception and design of the review: Conti L, Del Cornò M, Gessani S
Contributed to the literature search, revision and editing of this manuscript: Scazzocchio B, Varì R,
D’Archivio M, Varano B
Made substantial contribution to discussion: Masella R

Availability of data and materials
Not applicable.

Financial support and sponsorship
This study was supported by a grant of the Italian Association for Cancer Research (AIRC) project (IG2013
N.14185) to Gessani S.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.