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Figure 2. Strategies for CTC enrichment. A: A magnetic sifter device for CTC isolation when a magnetic field is applied. Magnetically labeled
CTCs are captured at the edges of the pores, while unlabeled cells pass through the pores under fluid flow; B: dual antibodies (anti-EpCAM
and anti-CD146) and biodegradable gelatin nanoparticle-coated microbeads for the capture of mesenchymal CTCs; C: a microfluidic
device embedded a wedge-shaped microchamber for cell separation based on multiple biophysical properties; D: a 3D bionic cytosensor
with PLGA nanofibers for CTC capture; E: vortex technology exploited for CTC isolating; F: a multizone velocity valley device for isolating
heterogeneous CTCs in four different regions of varying linear velocities; G: the hollow glass microspheres with nanotopographical
structures (NSHGMS) for excellent CTC isolation; H: a microfluidic device embedded a pyramid-shaped microchamber for size-based
CTC separation; I: a MagRC approach for separating and in-line profiling of heterogeneous CTCs. A: Copyright Royal Society of Chemistry,
[13]
2013. Reproduced with permission from reference ; B: Copyright Ivyspring International Publisher, 2013. Reproduced with permission
from reference [27] ; C: Copyright Royal Society of Chemistry, 2018. Reproduced with permission from reference [42] ; D: Copyright BioMed
Central, 2018. Reproduced with permission from reference [43] ; E: Copyright Nature, 2017. Reproduced with permission from reference [45] ;
F: Copyright Wiley, 2015. Reproduced with permission from reference [46] ; G: Copyright Institute Of Electrical And Electronics Engineers,
2018. Reproduced with permission from reference [52] ; H: Copyright Springer, 2018. Reproduced with permission from reference [53] ; I:
Copyright Wiley, 2018. Reproduced with permission from reference [54]