Page 66 - Read Online

Jusino et al. J Cancer Metastasis Treat 2018;4:43 I http://dx.doi.org/10.20517/2394-4722.2018.24 Page 19 of 20

148. Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans
SM, Fuchs E, Cleveland DW. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A 2015;112:E6321-30.
149. Marthiens V, Rujano MA, Pennetier C, Tessier S, Paul-Gilloteaux P, Basto R. Centrosome amplification causes microcephaly. Nat Cell
Biol 2013;15:731-40.
150. Lee M, Oprea-Ilies G, Saavedra HI. Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis.
Oncotarget 2015;6:37316-34.
151. Schneeweiss A, Sinn HP, Ehemann V, Khbeis T, Neben K, Krause U, Ho AD, Bastert G, Kramer A. Centrosomal aberrations in primary
invasive breast cancer are associated with nodal status and hormone receptor expression. Int J Cancer 2003;107:346-52.
152. Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is
prognostic of worse outcomes in breast cancer. BMC Cancer 2016;16:47.
153. Pannu V, Mittal K, Cantuaria G, Reid MD, Li X, Donthamsetty S, McBride M, Klimov S, Osan R, Gupta MV, Rida PC, Aneja R. Rampant
centrosome amplification underlies more aggressive disease course of triple negative breast cancers. Oncotarget 2015;6:10487-97.
154. Basto R, Brunk K, Vinadogrova T, Peel N, Franz A, Khodjakov A, Raff JW. Centrosome amplification can initiate tumorigenesis in flies.
Cell 2008;133:1032-42.
155. Castellanos E, Dominguez P, Gonzalez C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to
genome instability. Curr Biol 2008;18:1209-14.
156. Suizu F, Ryo A, Wulf G, Lim J, Lu KP. Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification,
chromosome instability, and oncogenesis. Mol Cell Biol 2006;26:1463-79.
157. Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T, Deng CX. Overexpression of aurora kinase A in mouse mammary
epithelium induces genetic instability preceding mammary tumor formation. Oncogene 2006;25:7148-58.
158. Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz
M, Glover DM. Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the
mouse. Open Biol 2015;5:150209.
159. Sercin O, Larsimont JC, Karambelas AE, Marthiens V, Moers V, Boeckx B, Le Mercier M, Lambrechts D, Basto R, Blanpain C.
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis. Nat Cell Biol 2016;18:100-10.
160. Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland
AJ. Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals. Dev Cell 2017;40:313-22.e5.
161. Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Thery M, Pellman D. Oncogene-like induction of
cellular invasion from centrosome amplification. Nature 2014;510:167-71.
162. Lee M, Oprea-Ilies G, Saavedra HI. Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis.
Oncotarget 2015;6:37316-34.
163. Schnerch D, Nigg EA. Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of
breast epithelial mammospheres. Oncogene 2016;35:2711-22.
164. Casenghi M, Meraldi P, Weinhart U, Duncan PI, Korner R, Nigg EA. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
microtubule nucleation. Dev Cell 2003;5:113-25.
165. Shao S, Liu R, Wang Y, Song Y, Zuo L, Xue L, Lu N, Hou N, Wang M, Yang X, Zhan Q. Centrosomal Nlp is an oncogenic protein that
is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. J Clin Invest 2010;120:498-507.
166. Yu L, Song Y, Zhang Q, Zhan Q. Ninein-like protein is overexpressed in head and neck squamous cell carcinoma and contributes to
cancer growth and resistance to apoptosis. Oncol Rep 2009;22:789-98.
167. Qu D, Qu H, Fu M, Zhao X, Liu R, Sui L, Zhan Q. Increased expression of Nlp, a potential oncogene in ovarian cancer, and its
implication in carcinogenesis. Gynecol Oncol 2008;110:230-6.
168. Ganier O, Schnerch D, Oertle P, Lim RY, Plodinec M, Nigg EA. Structural centrosome aberrations promote non-cell-autonomous
invasiveness. EMBO J 2018;37:e98576.
169. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. Science
1996;271:1744-7.
170. Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, Clevers H. Mutations in
the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 2001;3:433-8.
171. Tutt A, Gabriel A, Bertwistle D, Connor F, Paterson H, Peacock J, Ross G, Ashworth A. Absence of Brca2 causes genome instability by
chromosome breakage and loss associated with centrosome amplification. Curr Biol 1999;9:1107-10.
172. Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX. Genetic interactions between Brca1 and Gadd45a in
centrosome duplication, genetic stability, and neural tube closure. J Biol Chem 2004;279:29606-14.
173. Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR. Role for E2F in control of both DNA replication and mitotic
functions as revealed from DNA microarray analysis. Mol Cell Biol 2001;21:4684-99.
174. Harrison Pitner MK, Saavedra HI. Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.
PLoS One 2013;8:e65971.
175. Leontovich AA, Salisbury JL, Veroux M, Tallarita T, Billadeau D, McCubrey J, Ingle J, Galanis E, D’Assoro AB. Inhibition of Cdk2
activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells. Oncol Rep
2013;29:1785-8.
176. Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and
E2F. Nature 1997;387:422-6.
177. Iovino F, Lentini L, Amato A, Di Leonardo A. RB acute loss induces centrosome amplification and aneuploidy in murine primary