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Sawayama et al. J Cancer Metastasis Treat 2018;4:10  I  http://dx.doi.org/10.20517/2394-4722.2017.79                    Page 11 of 15


               The microenvironments of GC are associated with lymphatic invasion, vascular invasion, lymph
               node metastasis and survival of GC patients [Table 1]. The interaction between GC cells and the
               microenvironments of GC is increasingly being recognized, and the microenvironments of GC, as well as GC
               cells, may have become a target of anticancer strategies. Future studies may investigate whether inhibitors of
               the interaction between GC cells and the microenvironments improve GC patient prognosis in preclinical
               studies. Much research in the field of microenvironments of GC and the accumulation of molecular
               biological investigation are important for improving the management of GC and overcoming this disease in
               the future.



               DECLARATIONS
               Authors’ contributions
               Drafting of the manuscript: Sawayama H
               Critical revision of the manuscript for important intellectual content: Ishimoto T, Baba H

               Financial support and sponsorship
               None.

               Conflicts of interest
               There are no conflicts of interest.

               Patient consent
               Not applicable.


               Ethics approval
               Not applicable.


               Copyright
               © The Author(s) 2018.


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