Page 90 - Read Online
P. 90

Pippione et al.                                                                                                                                                             Steroidogenic enzymes in prostate cancer

               82.                                               PC, McConnell JD, Andriole GL, Geller J, Bracken BR, Tenover JS,
           74.  Poirier D. 17beta-Hydroxysteroid dehydrogenase inhibitors: a patent   Vaughan ED, Pappas F, Taylor A, Binkowitz B, Ng J. The effect of
               review. Expert Opin Ther Pat 2010;20:1123-45.     finasteride in men with benign prostatic hyperplasia. 1992. J Urol
           75.  Day JM, Tutill HJ, Purohit A. 17ss-hydroxysteroid dehydrogenase   2002;167:1102-8.
               inhibitors. Minerva Endocrinol 2010;35:87-108.  91.  Roehrborn CG, Boyle P, Nickel JC, Hoefner K, Andriole G. Efficacy
           76.  Olusanjo MS, Ahmed S. Inhibitors of 17-hydroxysteroid   and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2
               dehydrogenase type 3 (17-beta-HSD 3). Drugs Future 2009;34:555.  (dutasteride) in men with benign prostatic hyperplasia. Urology
           77.  Ning X, Yang Y, Deng H, Zhang Q, Huang Y, Su Z, Fu Y, Xiang Q,   2002;60:434-41.
               Zhang S. Development of 17β-hydroxysteroid dehydrogenase type   92.  Faller B, Farley D, Nick H. Finasteride: a slow-binding 5 alpha-
               3 as a target in hormone-dependent prostate cancer therapy. Steroids   reductase inhibitor. Biochemistry 1993;32:5705-10.
               2017;121:10-6.                                 93.  Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An
           78.  Fink BE, Gavai AV, Tokarski JS, Goyal B, Misra R, Xiao HY,   overview on 5alpha-reductase inhibitors. Steroids 2010;75:109-53.
               Kimball SD, Han WC, Norris D, Spires TE, You D, Gottardis   94.  Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB,
               MM, Lorenzi MV, Vite GD. Identification of a novel series of   Hobbs S. Marked suppression of dihydrotestosterone in men with
               tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid   benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase
               dehydrogenase type 3. Bioorg Med Chem Lett 2006;16:1532-6.  inhibitor. J Clin Endocrinol Metab 2004;89:2179-84.
           79.  Vicker N, Sharland CM, Heaton WB, Gonzalez AM, Bailey HV,   95.  Salvador JA, Pinto RM, Silvestre SM. Steroidal 5alpha-reductase
               Smith A, Springall JS, Day JM, Tutill HJ, Reed MJ, Purohit A, Potter   and 17alpha-hydroxylase/17,20-lyase (CYP17) inhibitors useful
               BV. The design of novel 17beta-hydroxysteroid dehydrogenase type 3   in the treatment of prostatic diseases. J Steroid Biochem Mol Biol
               inhibitors. Mol Cell Endocrinol 2009;301:259-65.  2013;137:199-222.
           80.  Nashev LG, Schuster D, Laggner C, Sodha S, Langer T, Wolber   96.  Holt DA, Levy MA, Oh HJ, Erb JM, Heaslip JI, Brandt M, Lan-
               G, Odermatt A. The UV-filter benzophenone-1 inhibits 17beta-  Hargest HY, Metcalf BW. Inhibition of steroid 5 alpha-reductase by
               hydroxysteroid dehydrogenase type 3: virtual screening as a strategy   unsaturated 3-carboxysteroids. J Med Chem 1990;33:943-50.
               to identify potential endocrine disrupting chemicals. Biochem   97.  Yao Z, Xu Y, Zhang M, Jiang S, Nicklaus MC, Liao C. Discovery of a
               Pharmacol 2010;79:1189-99.                        novel hybrid from finasteride and epristeride as 5α-reductase inhibitor.
           81.  Schuster D, Kowalik D, Kirchmair J, Laggner C, Markt P, Aebischer-  Bioorg Med Chem Lett 2011;21:475-8.
               Gumy C, Strohle F, Moller G, Wolber G, Wilckens T, Langer T,   98.  Aggarwal S, Thareja S, Bhardwaj TR, Haupenthal J, Hartmann RW,
               Odermatt A, Adamski J. Identification of chemically diverse, novel   Kumar M. Synthesis and biological evaluation of novel unsaturated
               inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 and 5 by   carboxysteroids as human 5alpha-reductase inhibitors: a legitimate
               pharmacophore-based virtual screening. J Steroid Biochem Mol Biol   approach. Eur J Med Chem 2012;54:728-39.
               2011;125:148-61.                               99.  Kim S, Kim Y-U, Ma E. Synthesis and 5α-reductase inhibitory activity
           82.  Guzi TJ, Liu Y-T, Doll RJ, Saksena A, Girijavallabhan VM, Pachter   of C21 steroids having 1,4-diene or 4,6-diene 20-ones and 4-azasteroid
               JA. Preparation of 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]  20-oximes. Molecules 2012;17:355-68.
               pyridine derivatives as 17 beta-hydroxysteroid dehydrogenase   100. Al-Mohizea AM, Al-Omar MA, Abdalla MM, Amr AG. 5alpha-
               type 3 inhibitors for the treatment of androgen dependent diseases.   reductase inhibitors, antiviral and anti-tumor activities of some
               Kenilworth, USA; Schering Corporation; 2004. p. 72.  steroidal cyanopyridinone derivatives.  Int J Biol Macromol
           83.  Day JM, Foster PA, Tutill HJ, Schmidlin F, Sharland CM, Hargrave   2012;50:171-9.
               JD, Vicker N, Potter BV, Reed MJ, Purohit A. STX2171, a 17beta-  101. Lacy JM, Kyprianou N. A tale of two trials: the impact of 5α-reductase
               hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo   inhibition on prostate cancer (Review). Oncol Lett 2014;8:1391-6.
               in a novel hormone-dependent prostate cancer model. Endocr Relat   102. FDA Drug Safety Communication: 5-alpha reductase inhibitors (5-
               Cancer 2013;20:53-64.                             ARIs) may increase the risk of a more serious form of prostate cancer.
           84.  Harada K, Kubo H, Tomigahara Y, Nishioka K, Takahashi J, Momose   Available from: https://www.fda.gov/Drugs/DrugSafety/ucm258314.
               M, Inoue S, Kojima A. Coumarins as novel 17beta-hydroxysteroid   htm. [Last accessed on 13 Nov 2017]
               dehydrogenase type 3 inhibitors for potential treatment of prostate   103. Fleshner NE, Lucia MS, Egerdie B, Aaron L, Eure G, Nandy I,
               cancer. Bioorg Med Chem Lett 2010;20:272-5.       Black L, Rittmaster RS. Dutasteride in localised prostate cancer
           85.  Harada K, Kubo H, Abe J, Haneta M, Conception A, Inoue S,   management: the REDEEM randomised, double-blind, placebo-
               Okada S, Nishioka K. Discovery of potent and orally bioavailable   controlled trial. Lancet 2012;379:1103-11.
               17β-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg Med   104. Schroder F, Bangma C, Angulo JC, Alcaraz A, Colombel M,
               Chem 2012;20:3242-54.                             McNicholas T, Tammela TL, Nandy I, Castro R. Dutasteride treatment
           86.  Ohno S, Nakajima Y, Nakajin S. Triphenyltin and tributyltin inhibit   over 2 years delays prostate-specific antigen progression in patients
               pig testicular 17beta-hydroxysteroid dehydrogenase activity and   with biochemical failure after radical therapy for prostate cancer:
               suppress testicular testosterone biosynthesis. Steroids 2005;70:645-51.  results from the randomised, placebo-controlled Avodart After Radical
           87.  Titus MA, Li Y, Kozyreva OG, Maher V, Godoy A, Smith GJ, Mohler   Therapy for Prostate Cancer Study (ARTS). Eur Urol 2013;63:779-
               JL. 5α-reductase type 3 enzyme in benign and malignant prostate.   87.
               Prostate (Hoboken, NJ, U S) 2014;74:235-49.    105. Ramalingam S, Ramamurthy VP, Njar VC. Dissecting major
           88.  Azzouni F, Godoy A, Li Y, Mohler J. The 5 alpha-reductase isozyme   signaling pathways in prostate cancer development and progression:
               family: a review of basic biology and their role in human diseases.   Mechanisms and novel therapeutic targets. J Steroid Biochem Mol
               Adv Urol 2012;2012:530121.                        Biol 2017;166:16-27.
           89.  Li J, Ding Z, Wang Z, Lu JF, Maity SN, Navone NM, Logothetis   106. Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Reddy Bollu
               CJ, Mills GB, Kim J. Androgen regulation of 5alpha-reductase   L, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, Frigo DE.
               isoenzymes in prostate cancer: implications for prostate cancer   Identification of a novel coregulator, SH3YL1, that interacts with the
               prevention. PLoS One 2011;6:e28840.               androgen receptor N-terminus. Mol Endocrinol 2015;29:1426-39.
           90.  Gormley GJ, Stoner E, Bruskewitz RC, Imperato-McGinley J, Walsh   107. Dubbink HJ, Hersmus R, Verma CS, van der Korput HA, Berrevoets

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