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Webber et al. J Cancer Metastasis Treat 2018;4:1-3 Journal of
DOI: 10.20517/2394-4722.2018.46
Cancer Metastasis and Treatment

www.jcmtjournal.com
Topic: How does the prostate cancer microenvironment affect the metastatic Open Access
process and/or treatment outcome?

Introduction of the special issue “How does
the prostate cancer microenvironment affect

the metastatic process and/or treatment
outcome?”

Jason P. Webber , Klaus Pors 2
1
1 Tissue Microenvironment Group, Division of Cancer & Genetics, School of Medicine, Tenovus Building, Cardiff University, Cardiff CF14 4XN, UK.
2 Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK.
Correspondence to: Dr. Jason P. Webber, Tissue Microenvironment Group, Division of Cancer & Genetics, School of Medicine, Tenovus Building,
Cardiff University, Cardiff CF14 4XN, UK. E-mail: WebberJP@Cardiff.ac.uk; Dr. Klaus Pors, Institute of Cancer Therapeutics, Faculty of Life Sciences,
University of Bradford, Bradford BD7 1DP, UK. E-mail: k.pors1@bradford.ac.uk

How to cite this article: Webber JP, Pors K. Introduction of the special issue “How does the prostate cancer microenvironment affect the metastatic
process and/or treatment outcome?”. J Cancer Metastasis Treat 2018;4:1-3.
Article history: Received: 14 Jul 2018 Accepted: 16 Jul 2018 Published: 21 Aug 2018

It is with great pleasure that we introduce this present nine articles detailing the current state of art
special issue titled “How does the prostate cancer regarding development of aggressive prostate cancer.
microenvironment affect the metastatic process and/
or treatment outcome?”. Within this issue we, and our Current methods of prostate cancer diagnosis lack
fellow authors, explore the role of the prostate cancer both sensitivity and specificity. This can result in
microenvironment in tumour metastasis and treatment failed diagnosis of men likely to develop aggressive
outcome. Global statistics reveal that prostate cancer disease and over-treatment of men who do not require
is the second most common form of cancer and is treatment who consequently suffer as a result. It is
attributable to fifth of all cancer-related deaths to affect clear that if we are to improve the current paradigm
men worldwide. Whilst rates of disease incidence clinicians and scientists must work together. The first
and the last articles in this special issue, written by
appear to be increasing a high proportion of men Mason and Maitland , explores how to improve
[1]
[2]
diagnosed with disease will survive for ten or more on preclinical models and collaboration between
years. Yet, for some men, the disease is far more scientists and clinicians in combined efforts towards
aggressive, resulting in tumour metastasis and failed improving the quality of lives of patients living with
response to treatment. Improving our knowledge of the prostate cancer.
prostate cancer microenvironment will undoubtedly
lead to opportunities for providing better treatment With our improved understanding of the prostate cancer
options for patients with aggressive forms of this development, it is clear that our attitudes towards cancer
disease. To address this gap in knowledge, we here diagnosis and therapeutic intervention need to evolve

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