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Page 8 of 15 Wang et al. Hepatoma Res 2020;6:61 I http://dx.doi.org/10.20517/2394-5079.2020.55

2018 CellSearch 73 HCC patients Spatial heterogeneity of Multi-vascular measurement of ●●●○ [27]
phenotypic and molecular CTCs facilitates precise prediction of Moderate
characteristics of CTCs postoperative relapse or metastasis
pattern; profound spatial heterogeneity
in cellular distribution and biological
features of CTCs during circulation
2018 CellSearch 139 HCC patients Prognostic significance of Both CTC detection incidence and mean ●●○○ [79]
CTCs and effect of liver CTC counts increased postoperatively; Low
resection on CTCs increased postoperative CTC numbers
were associated with a worse prognosis
2018 CellSearch 97 HCC patients Prognostic significance of High EpCAM-positive CTC count ●●○○ [81]
CTCs in predicting survival predicts poor survival of patients Low
outcomes of patients with with unresectable HCC treated with
unresectable HCC treated chemoembolization
with TACE
2018 qRT-PCR- 445 HCC patients Clinical value of CTCs with CTC panel may be a useful tool in HCC ●●●○ [63]
based stem-like phenotypes for diagnosis, risk prediction, and treatment Moderate
platform diagnosis, prognosis, and response monitoring
surveillance in HBV-related
HCC
2018 CanPatrol 165 HCC patients Prognostic significance of Presence of mesenchymal CTCs ●●●○ [89]
platform EMT phenotypes of CTCs predicted the shortest relapse-free Moderate
after surgical resection survival
+
2018 CanPatrol 80 HCC patients Relationship between Twist CTCs were closely correlated with ●●○○ [90]
platform expression of Twist in the rate of metastasis or recurrence and Low
CTCs and HCC clinical the mortality rate in HCC
parameters
2018 CanPatrol 42 HCC patients Prognostic significance of Unfavorable changes after surgery ●●○○ [91]
platform the change of CTC numbers in CTC counts may be independent Low
in tumor recurrence and prognostic indicators for PFS in patients
metastasis after surgical with HBV-related HCC
resection
2018 CanPatrol 62 HCC patients Relationship between HCC patients with positive ●○○○ [93]
platform postoperative circulating postoperative peripheral mesenchymal Very Low
tumor cells subtypes and CTCs had a higher risk of early
HCC recurrence recurrence
2018 CanPatrol 112 HCC patients Prognostic significance of CTCs were highly correlated with HCC ●●●○ [94]
platform EMT phenotypes of CTCs characteristics, representing a novel Moderate
after surgical resection marker for early diagnosis and early
recurrence prediction
2018 CanPatrol 47 HCC patients Prognostic significance of CTC levels and subtypes were not ●○○○ [96]
platform EMT phenotypes of CTCs in predictive of HCC recurrence following Very Low
HCC patients treated with liver transplantation
liver transplantation
2018 iFISH platform 30 HCC patients Prognostic significance iFISH-CTC ≥ 5 may be a good prognostic ●○○○ [97]
of CTCs in HCC patients indicator for patients with HCC Very Low
treated with liver undergoing liver transplantation
transplantation
2018 Flow 43 patients with Effect of percutaneous Liver tumor ablation might increase the ●○○○ [103]
cytometric liver malignant radiofrequency ablation on level of mesenchymal phenotype CTCs Very Low
analysis tumor CTCs
2018 Flow HCC orthotopic Monitor CTC dynamics EGFR inhibitor application may ●○○○ [108]
cytometry metastatic tumor following transcatheter reduce circulating cancer cells during Very Low
model (mouse) arterial embolization transcatheter arterial embolization and
improve the therapeutic outcomes for
advanced HCC
2019 CanPatrol 113 HCC patients Diagnostic value of different Total CTCs were more effective than ●●○○ [92]
platform EMT phenotypes of CTC in AFP in the diagnosis of HCC; combined Low
HCC use of total CTCs and AFP can enhance
the sensitivity of HCC diagnosis
2019 CanPatrol 256 HCC patients Prognostic significance of CTC count and EMT classification were ●○○○ [95]
platform EMT phenotypes of CTCs not correlated with clinical stages or Very Low
after surgical resection predictive of HCC recurrence
2019 Tapered slit 105 HCC patients Monitor CTC before Count of ΔCTC is predictive of ●●○○ [100]
filter platform and after surgery and its recurrence in patients with early HCC Low
association with clinical undergoing surgery
outcomes in early-stage
HCC