Page 338 - Read Online
P. 338

Shrestha et al. Hepatoma Res 2019;5:32  I  http://dx.doi.org/10.20517/2394-5079.2019.24                                        Page 15 of 17

               46.  Xu F, Jin T, Zhu Y, Dai C. Immune checkpoint therapy in liver cancer. J Exp Clin Cancer Res 2018;37:110.
               47.  Calderaro J, Rousseau B, Amaddeo G, Mercey M, Charpy C, et al. Programmed death ligand 1 expression in hepatocellular
                   carcinoma: Relationship With clinical and pathological features. Hepatology 2016;64:2038-46.
               48.  Chang H, Jung W, Kim A, Kim HK, Kim WB, et al. Expression and prognostic significance of programmed death protein 1 and
                   programmed death ligand-1, and cytotoxic T lymphocyte-associated molecule-4 in hepatocellular carcinoma. APMIS 2017;125:690-8.
               49.  Sideras K, Biermann K, Verheij J, Takkenberg BR, Mancham S, et al. PD-L1, Galectin-9 and CD8. Oncoimmunology 2017;6:e1273309.
               50.  Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is
                   mediated by B7-H1/programmed death-1 interactions. Cancer Res 2009;69:8067-75.
               51.  Wainberg ZA, Segal NH, Jaeger D, Lee K-H, Marshall J, et al. Safety and clinical activity of durvalumab monotherapy in patients with
                   hepatocellular carcinoma (HCC). J Clin Oncol 2017;35:4071.
               52.  Nishida N, Kudo M. Immune checkpoint blockade for the treatment of human hepatocellular carcinoma. Hepatol Res 2018;48:622-34.
               53.  Cella D, Grünwald V, Escudier B, Hammers HJ, George S, et al. Patient-reported outcomes of patients with advanced renal cell
                   carcinoma treated with nivolumab plus ipilimumab versus sunitinib (CheckMate 214): a randomised, phase 3 trial. Lancet Oncol
                   2019;20:297-310.
               54.  Jain S, Clark JI. Ipilimumab for the treatment of melanoma. Melanoma Manag 2015;2:33-9.
               55.  Kelley RK, Abou-Alfa GK, Bendell JC, Kim T-Y, Borad MJ, et al. Phase I/II study of durvalumab and tremelimumab in patients with
                   unresectable hepatocellular carcinoma (HCC): Phase I safety and efficacy analyses. J Clin Oncol 2017;35:4073.
               56.  Abou-Alfa GK, Chan SL, Furuse J, Galle PR, Kelley RK, et al. A randomized, multicenter phase 3 study of durvalumab (D) and
                   tremelimumab (T) as first-line treatment in patients with unresectable hepatocellular carcinoma (HCC): HIMALAYA study. J Clin
                   Oncol 2018;36:TPS4144.
               57.  Finn RS, Ducreux M, Qin S, Galle PR, Zhu AX, et al. IMbrave150: A randomized phase III study of 1L atezolizumab plus
                   bevacizumab vs sorafenib in locally advanced or metastatic hepatocellular carcinoma. J Clin Oncol 2018;36:TPS4141.
               58.  J Pishvaian M, S Lee M, Ryoo BY, Stein S, Lee KH, et al. LBA26Updated safety and clinical activity results from a phase Ib study of
                   atezolizumab + bevacizumab in hepatocellular carcinoma (HCC); Ann Oncol 2018;29; DOI:10.1093/annonc/mdy424.028.
               59.  Ikeda M, Sung MW, Kudo M, Kobayashi M, Baron AD, et al. A phase 1b trial of lenvatinib (LEN) plus pembrolizumab (PEM) in
                   patients (pts) with unresectable hepatocellular carcinoma (uHCC). J Clin Oncol 2018;36:4076.
               60.  Xue JM, Astère M, Zhong MX, Lin H, Shen J, et al. Efficacy and safety of apatinib treatment for gastric cancer, hepatocellular
                   carcinoma and non-small cell lung cancer: a meta-analysis. Onco Targets Ther 2018;11:6119-28.
               61.  Deng L, Liang H, Burnette B, Beckett M, Darga T, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor
                   immunity in mice. J Clin Invest 2014;124:687-95.
               62.  Kreidieh M, Zeidan YH, Shamseddine A. The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary
                   Liver Tumors. J Oncol 2019;2019:4304817.
               63.  Harding JJ, Erinjeri JP, Tan BR, Reiss KA, Mody K, et al. A multicenter pilot study of nivolumab (NIVO) with drug eluting bead
                   transarterial chemoembolization (deb-TACE) in patients (pts) with liver limited hepatocellular carcinoma (HCC). J Clin Oncol
                   2018;36:TPS4146.
               64.  Duffy AG, Ulahannan SV, Makorova-Rusher O, Rahma O, Wedemeyer H, et al. Tremelimumab in combination with ablation in
                   patients with advanced hepatocellular carcinoma. J Hepatol 2017;66:545-51.
               65.  Chang EWY, Tai DW-M, Koo S-L, Ng MC, Yeong JPS, et al. A phase II open-label, single-centre, non-randomized trial of Y90
                   transarterial radioembolization in combination with nivolumab in Asian patients with intermediate stage hepatocellular carcinoma:
                   An immunological study of radioembolization in combination with anti-PD1 therapy in HCC. J Clin Oncol 2018;36:TPS542.
               66.  Hecht JR, Prat A, Pless M, Cubillo A, Calvo A, et al. A phase 1b/2, multicenter, open-label trial to evaluate the safety of talimogene
                   laherparepvec (T-VEC) injected into primary and metastatic liver tumors alone and in combination with pembrolizumab (pembro)
                   (MASTERKEY-318). J Clin Oncol 2018;36:TPS3105.
               67.  Jenkins RW, Barbie DA, Flaherty KT. Mechanisms of resistance to immune checkpoint inhibitors. Br J Cancer 2018;118:9-16.
               68.  Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, et al. Fulminant Myocarditis with Combination Immune Checkpoint
                   Blockade. N Engl J Med 2016;375:1749-55.
               69.  Winer A, Bodor JN, Borghaei H. Identifying and managing the adverse effects of immune checkpoint blockade. J Thorac Dis
                   2018;10:S480-S9.
               70.  Puzanov I, Diab A, Abdallah K, Bingham CO, Brogdon C, et al; Group SfIoCTMW. Managing toxicities associated with immune
                   checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management
                   Working Group. J Immunother Cancer 2017;5:95.
               71.  McLoughlin KC, Brown ZJ, Shukla Y, Shukla V. Promise and pitfalls of immune checkpoint inhibitors in hepato-pancreato-biliary
                   malignancies. Discov Med 2018;26:85-92.
               72.  Koyama S, Akbay EA, Li YY, Herter-Sprie GS, Buczkowski KA, et al. Adaptive resistance to therapeutic PD-1 blockade is associated
                   with upregulation of alternative immune checkpoints. Nat Commun 2016;7:10501.
               73.  Peng W, Chen JQ, Liu C, Malu S, Creasy C, et al. Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. Cancer
                   Discov 2016;6:202-16.
               74.  Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, et al. Gut microbiome modulates response to anti-PD-1
                   immunotherapy in melanoma patients. Science 2018;359:97-103.
               75.  Ma C, Han M, Heinrich B, Fu Q, Zhang Q, et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.
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