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Zhang et al. Hepatoma Res 2019;5:27 I http://dx.doi.org/10.20517/2394-5079.2019.13 Page 17 of 18

Cancer Biomark 2019;24:97-107.
149 Sui X, Geng JH, Li YH, Zhu GY, Wang WH. Calcium channel α2δ1 subunit (CaCna2D1) enhances radioresistance in cancer stem-like
cells in non-small cell lung cancer cell lines. Cancer Manag Res 2018;10:5009-18.
150 Zhang Y, Zhao W, Han H, Li S, Chen D, et al. MicroRNA-31 suppresses the self-renewal capability of α2δ1+liver tumor-initiating cells
by targetingISL1. Oncotarget 2017;8:87647-57.
151 Roskams T, De Vos R, Van Eyken P, Myazaki H, Van Damme B, et al. Hepatic OV-6 expression in human liver disease and rat
experiments: evidence for hepatic progenitor cells in man. J Hepatol 1998;29:455-63.
152 Yang W, Yan HX, Chen L, Liu Q, He YQ, et al. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver
progenitor cells. Cancer Res 2008;68:4287-95.
153. Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1.
2003;116:1775-86.
154 Huang J, Zhang X, Zhang M, Zhu JD, Zhang YL, et al. Up-regulation of DLK1 as an imprinted gene could contribute to human
hepatocellular carcinoma. Carcinogenesis 2007;28:1094-103.
155 Xu X, Liu RF, Zhang X, Huang LY, Chen F, et al. DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular
carcinoma. Mol Cancer Ther 2012;11:629-38.
156 Stosiek P, Kasper M, Karsten U. Expression of cytokeratin 19 during human liver organogenesis. Liver 2010;10:59-63.
157 Kawai T, Yasuchika K, Seo S, Higashi T, Ishii T, et al. Identification of keratin 19-positive cancer stem cells associating human
hepatocellular carcinoma using 18f-fluorodeoxyglucose positron emission tomography. Clin Cancer Res 2017;23:1450-60.
158 Govaere O, Petz M, Wouters J, Vandewynckel YP, Scott EJ, et al. The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression
at the invasive front of human hepatocellular carcinoma. Oncogene 2017;36:6605-16.
159 Rhee H, Kim HY, Choi JH, Woo HG, Yoo JE, et al. Keratin 19 expression in hepatocellular carcinoma is regulated by fibroblast-derived
HGF via a MET-ERK1/2-AP1 and SP1 axis. Cancer Res 2018;78:1619-31.
160 Govaere O, Komuta M, Berkers J, Spee B, Janssen C, et al. Keratin 19: a key role player in the invasion of human hepatocellular
carcinomas. Gut 2014;63:674-85.
161 Kim H, Choi GH, Na DC, Ahn EY, Kim GI, et al. Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin
19 expression and a poor prognosis. Hepatology 2011;54:1707-17.
162 Bae JS, Choi HN, Noh SJ, Park BH, Jang KY, et al. Expression of K19 and K7 in dysplastic nodules and hepatocellular carcinoma. Oncol
Lett 2012;4:213-20.
163 Fatourou E, Koskinas J, Karandrea D, Palaiologou M, Syminelaki T, et al. Keratin 19 protein expression is an independent predictor of
survival in human hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2015;27:1094-102.
164 Kowalik MA, Sulas P, Ledda-Columbano GM, Giordano S, Columbano A, et al. Cytokeratin-19 positivity is acquired along cancer
progression and does not predict cell origin in rat hepatocarcinogenesis. Oncotarget 2015;6:38749-63.
165 de Lau W, Barker N, Low TY, Koo BK, Li VS, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature 2011;476:293-7.
166 Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet
2008;40:1291-9.
167 Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build
long-lived gastric units in vitro. Cell Stem Cell 2010;6:25-36.
168 Plaks V, Brenot A, Lawson D, Linnemann JR, Vankappel EC, et al. Lgr5 -Expressing Cells Are Sufficient and Necessary for Postnatal
Mammary Gland Organogenesis. Cell Rep 2013;3:70-8.
169 Ng A, Tan S, Singh G, Rizk P, Swathi Y, et al. Lgr5 marks stem/progenitor cells in ovary and tubal epithelia. Nat Cell Biol 2014;16:745-
57.
170 Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the
Lgr5/R-spondin axis. EMBO J 2013;32:2708-21.
171 Leushacke M, Si HT, Wong A, Swathi Y, Hajamohideen A, et al. Lgr5-expressing chief cells drive epithelial regeneration and cancer in
the oxyntic stomach. Nat Cell Biol 2017;19:774-86.
172 Barker N, Van Es JH, Kuipers J, Kujala P, Van Den Born M, et al. Identification of stem cells in small intestine and colon by marker gene
Lgr5. Nature 2007;449:1003-7.
173 Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, et al. Visualization and targeting of LGR5+ human colon cancer stem cells.
Nature 2017;547:187-92.
174 de Lau W, Peng WC, Gros P, Clevers H. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev 2014;28:305-
16.
175 Lin Y, Fang ZP, Liu HJ, Wang LJ, Cheng Z, et al. HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+liver stem
cells. Nat Commun 2017;8:1175.
176 Effendi K, Yamazaki K, Fukuma M, Sakamoto M. Overexpression of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5
(LGR5) Represents a Typical Wnt/β-Catenin Pathway-Activated Hepatocellular Carcinoma. Liver Cancer 2014;3:451-7.
177 Lei ZJ, Wang J, Xiao HL, Guo Y, Wang T, et al. Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5(+)
liver cancer initiating cells by suppressing negative regulators of β-catenin signaling. Oncogene 2015;34:3188-98.
178 Lu B, Huang X, Mo J, Zhao W. Drug delivery using nanoparticles for cancer stem-like cell targeting. Front Pharmacol 2016;7:84.
179 Wang X, Low XC, Hou W, Abdullah LN, Toh TB, et al. Epirubicin-adsorbed nanodiamonds kill chemoresistant hepatic cancer stem