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Prajapati et al. TACE in recurrent HCC after OLT

shortest survival from DEB TACE was 3.4 months and A Survival fuctions
the patient had hepatitis B and more than 12 HCC 1.0 Alpha-fetoprotein
tumors with extra-hepatic metastasis and AFP > 2,400 (ng/dL)
ng/mL. Survival curves generated by Kaplan Meier 0: < 400
1: ≥400
analysis according to the status of AFP and metastases 0.8 0.0
are shown in the Figure 1A and B. The histology grading 1.0
of HCCs of the explant liver was correlated with the 0.6 0.0-censored
survivals. The patients with poorly differentiated HCC Cum survival 1.0-censored
had the poor overall survivals (3.4 months) compared 0.4

Table 2: Median survivals (from 1st DEB TACE) HCC 0.2
patients after OLT treated with DEB TACE
Number of Median survival P
Demographics patients (months) value 0.0
Total number of patients 8 15.6 0 10 20 30 40
Child-Pugh class Survival from 1st DEB TACE (months)
A 5 21.7 0.45
B 3 15.6 B Survival fuctions
Okuda staging 1.0 Extra-hepatic
I 6 9.3 0.9 metastasis
II 2 15.6 0: no
CLIP staging 0.8 1: yes
Early 3 39.4 0.0
Intermediate 5 15.6 0.2 0.6 1.0
ECOG performance status 0.0-censored
0 4 39.4 Cum survival 1.0-censored
1 3 21.7 0.3 0.4
2 1 7.7
Imaging findings 0.2
Ascites
Present 1 26.8 0.7
Absent 7 15.6 0.0
Portal hypertension
Present 4 7.8 0.2 0 10 20 30 40
Absent 4 21.7 Survival from 1st DEB TACE (months)
Tumor morphology C Survival fuctions
Tumor locations Histology
Unilobar 6 15.6 0.27 1.0 0: well or
Bilobar 2 3.4 moderately
Number of tumors 0.8 differentiated
Solitary 6 15.6 0.14 1: poorly
Multiple 2 3.4 differentiated
Size of index tumor 0.6 0.0
< 3 cm 6 15.6 Cum survival 1.0
3 cm or more 2 7.8 0.87 0.4 0.0-censored
Extrahepatic metastasis 1.0-censored
Present 2 3.4 0.03
Absent 6 21.7 0.2
Laboratory data
Serum alpha-fetoprotein level (ng/dL) of recurrent HCC 0.0
< 400 6 21.7 0.03
≥ 400 2 3.4 0 10 20 30 40
Histology grading of the explant liver HCC Survival from 1st DEB TACE (months)
Well or moderately 21.7 0.004
differentiated 6 Figure 1: Survival curves generated by Kaplan Meier analysis
Poorly differentiated 2 3.6 according to the status of alpha-fetoprotein level (A), presence or
absence of the extra-hepatic metastasis (B) and histology grading
HCC: hepatocellular carcinoma; DEB TACE: doxorubicin drug of the explant liver (C) before DEB TACE in patient with recurrent
eluting beads transcatheter arterial chemoembolization; OLT: HCC after orthotopic liver transplantation. HCC: hepatocellular
orthotopic liver transplantation; CLIP: Cancer of the Italian Liver carcinoma; DEB TACE: doxorubicin drug eluting beads
Program; ECOG: eastern cooperative oncology group transcatheter arterial chemoembolization
Hepatoma Research ¦ Volume 3 ¦ August 17, 2017 185