Page 194 - Read Online

245. Li L, Oropeza CE, Kaestner KH, McLachlan A. Limited effects of target of rapamycin (mTOR) signal and its implication for hepatitis
fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic B virus tumorigenesis and therapy. Hepatology 2011;54:1199-207.
mice. J Virol 2009;83:1682-8. 264. Wang CC, Tseng TC, Kao JH. Hepatitis B virus infection and
246. Ondracek CR, Reese VC, Rushing CN, Oropeza CE, McLachlan A. metabolic syndrome: fact or fiction? J Gastroenterol Hepatol
Distinct regulation of hepatitis B virus biosynthesis by peroxisome 2015;30:14-20.
proliferator-activated receptor gamma coactivator 1alpha and 265. Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett
small heterodimer partner in human hepatoma cell lines. J Virol JR, Penninger J, Richardson CD. X protein of hepatitis B virus
2009;83:12545-51. inhibits Fas-mediated apoptosis and is associated with up-regulation
247. Reese V, Ondracek C, Rushing C, Li L, Oropeza CE, McLachlan of the SAPK/JNK pathway. J Biol Chem 2001;276:8328-40.
A. Multiple nuclear receptors may regulate hepatitis B virus 266. Elmore LW, Hancock AR, Chang SF, Wang XW, Chang S, Callahan
biosynthesis during development. Int J Biochem Cell Biol CP, Geller DA, Will H, Harris CC. Hepatitis B virus X protein and
2011;43:230-7. p53 tumor suppressor interactions in the modulation of apoptosis.
248. Curtil C, Enache LS, Radreau P, Dron AG, Scholtès C, Deloire A, Proc Natl Acad Sci U S A 1997;94:14707-12.
Roche D, Lotteau V, Andre P, Ramière C. The metabolic sensors 267. Gottlob K, Fulco M, Levrero M, Graessmann A. The hepatitis
FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus B virus HBx protein inhibits caspase 3 activity. J Biol Chem
transcription. FASEB J 2014;28:1454-63. 1998;273:33347-53.
249. Reese VC, Oropeza CE, McLachlan A. Independent activation of 268. Lee YI, Kang-Park S, Do SI, Lee YI. The hepatitis B virus-X protein
hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, activates a phosphatidylinositol 3-kinase-dependent survival
and bile acids. J Virol 2013;87:991-7. signaling cascade. J Biol Chem 2001;276:16969-77.
250. Ramière C, Scholtès C, Diaz O, Icard V, Perrin-Cocon L, Trabaud 269. Pan J, Duan LX, Sun BS, Feitelson MA. Hepatitis B virus X protein
MA, Lotteau V, André P. Transactivation of the hepatitis B protects against anti-Fas-mediated apoptosis in human liver cells by
virus core promoter by the nuclear receptor FXRalpha. J Virol inducing NF-kappa B. J Gen Virol 2001;82:171-82.
2008;82:10832-40. 270. Klein A, Guhl E, Tzeng YJ, Fuhrhop J, Levrero M, Graessmann
251. Kim HY, Cho HK, Choi YH, Lee KS, Cheong J. Bile acids increase M, Graessmann A. HBX causes cyclin D1 overexpression and
hepatitis B virus gene expression and inhibit interferon-alpha development of breast cancer in transgenic animals that are
activity. FEBS J 2010;277:2791-802. heterozygous for p53. Oncogene 2003;22:2910-9.
252. Shlomai A, Paran N, Shaul Y. PGC-1alpha controls hepatitis 271. Madden CR, Finegold MJ, Slagle BL. Expression of hepatitis B
B virus through nutritional signals. Proc Natl Acad Sci U S A virus X protein does not alter the accumulation of spontaneous
2006;103:16003-8. mutations in transgenic mice. J Virol 2000;74:5266-72.
253. Shin HJ, Park YH, Kim SU, Moon HB, Park do S, Han YH, Lee CH, 272. Bergametti F, Prigent S, Luber B, Benoit A, Tiollais P, Sarasin A,
Lee DS, Song IS, Lee DH, Kim M, Kim NS, Kim DG, Kim JM, Transy C. The proapoptotic effect of hepatitis B virus HBx protein
Kim SK, Kim YN, Kim SS, Choi CS, Kim YB, Yu DY. Hepatitis B correlates with its transactivation activity in stably transfected cell
virus X protein regulates hepatic glucose homeostasis via activation lines. Oncogene 1999;18:2860-71.
of inducible nitric oxide synthase. J Biol Chem 2011;286:29872-81. 273. Chirillo P, Pagano S, Natoli G, Puri PL, Burgio VL, Balsano C,
254. Jagya N, Varma SP, Thakral D, Joshi P, Durgapal H, Panda SK. Levrero M. The hepatitis B virus X gene induces p53-mediated
RNA-seq based transcriptome analysis of hepatitis E virus (HEV) programmed cell death. Proc Natl Acad Sci U S A 1997;94:8162-7.
and hepatitis B virus (HBV) replicon transfected Huh-7 cells. PLoS 274. Kim H, Lee H, Yun Y. X-gene product of hepatitis B virus induces
One 2014;9:e87835. apoptosis in liver cells. J Biol Chem 1998;273:381-5.
255. Jhuang HJ, Hsu WH, Lin KT, Hsu SL, Wang FS, Chou CK, Lee 275. Su F, Theodosis CN, Schneider RJ. Role of NF-kappaB and myc
KH, Tsou AP, Lai JM, Yeh SF, Huang CY. Gluconeogenesis, proteins in apoptosis induced by hepatitis B virus HBx protein. J
lipogenesis, and HBV replication are commonly regulated by PGC- Virol 2001;75:215-25.
1α-dependent pathway. Oncotarget 2015;6:7788-803. 276. Terradillos O, de La Coste A, Pollicino T, Neuveut C, Sitterlin D,
256. Benn J, Schneider RJ. Hepatitis B virus HBx protein activates Ras- Lecoeur H, Gougeon ML, Kahn A, Buendia MA. The hepatitis B
GTP complex formation and establishes a Ras, Raf, MAP kinase virus X protein abrogates Bcl-2-mediated protection against Fas
signaling cascade. Proc Natl Acad Sci U S A 1994;91:10350-4. apoptosis in the liver. Oncogene 2002;21:377-86.
257. Doria M, Klein N, Lucito R, Schneider RJ. The hepatitis B virus 277. Lee YI, Hwang JM, Im JH, Lee YI, Kim NS, Kim DG, Yu DY,
HBx protein is a dual specificity cytoplasmic activator of Ras and Moon HB, Park SK. Human hepatitis B virus-X protein alters
nuclear activator of transcription factors. EMBO J 1995;14:4747- mitochondrial function and physiology in human liver cells. J Biol
57. Chem 2004;279:15460-71.
258. Gehart H, Kumpf S, Ittner A, Ricci R. MAPK signalling in cellular 278. Su F, Schneider RJ. Hepatitis B virus HBx protein sensitizes cells to
metabolism: stress or wellness? EMBO Rep 2010;11:834-40. apoptotic killing by tumor necrosis factor alpha. Proc Natl Acad Sci
259. Luber B, Lauer U, Weiss L, Hohne M, Hofschneider PH, Kekulé U S A 1997;94:8744-9.
AS. The hepatitis B virus transactivator HBx causes elevation 279. Wang WH, Gregori G, Hullinger RL, Andrisani OM. Sustained
of diacylglycerol and activation of protein kinase C. Res Virol activation of p38 mitogen-activated protein kinase and c-Jun
1993;144:311-21. N-terminal kinase pathways by hepatitis B virus X protein mediates
260. Zhu M, Guo J, Li W, Lu Y, Fu S, Xie X, Xia H, Dong X, Chen apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF)
Y, Quan M, Zheng S, Xie K, Li M. Hepatitis B virus X protein receptor 1/TNF-alpha expression. Mol Cell Biol 2004;24:10352-65.
induces expression of alpha-fetoprotein and activates PI3K/mTOR 280. Benhenda S, Cougot D, Buendia MA, Neuveut C. Hepatitis B virus
signaling pathway in liver cells. Oncotarget 2015;6:12196-208. X protein molecular functions and its role in virus life cycle and
261. Teng CF, Hsieh WC, Wu HC, Lin YJ, Tsai HW, Huang W, Su pathogenesis. Adv Cancer Res 2009;103:75-109.
IJ. Hepatitis B virus Pre-S2 mutant induces aerobic glycolysis 281. Ng SA, Lee C. Hepatitis B virus X gene and hepatocarcinogenesis.
through mammalian target of rapamycin signal cascade. PLoS One J Gastroenterol 2011;46:974-90.
2015;10:e0122373. 282. Arzberger S, Hösel M, Protzer U. Apoptosis of hepatitis B virus-
262. Teng CF, Wu HC, Hsieh WC, Tsai HW, Su IJ. Activation of ATP infected hepatocytes prevents release of infectious virus. J Virol
citrate lyase by mTOR signal induces disturbed lipid metabolism in 2010;84:11994-2001.
hepatitis B virus pre-S2 mutant tumorigenesis. J Virol 2015;89:605- 283. Brenner DA. Signal transduction during liver regeneration. J
14. Gastroenterol Hepatol 1998;13:S93-5.
263. Teng CF, Wu HC, Tsai HW, Shiah HS, Huang W, Su IJ. Novel 284. FitzGerald MJ, Webber EM, Donovan JR, Fausto N. Rapid DNA
feedback inhibition of surface antigen synthesis by mammalian binding by nuclear factor kappa B in hepatocytes at the start of liver
Hepatoma Research | Volume 2 | July 1, 2016 185