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            Special Issue
            Natural Products and Hepatocellular Carcinoma



            Guest Editor:                     Special Issue Introduction
            Mosaad Attia Abdel-               Hepatocellular carcinoma (HCC) is a major health problem, with more
            Wahhab, MD                        than 500,000 cases diagnosed annually. Natural products (NPs) are
                                              chemical compounds or substances produced by a living organism
            Food Toxicology and
                                              found in nature. Some NPs have benecial effects however; some
            Contaminants Department,
                                              others have toxic effects. Several mycotoxins were classied as
            National Research Center,
                                              hepatocarcinogenic. The most important mycotoxins is aatoxin B 1
            Dokki, Cairo 12622, Egypt.
                                              (AFB ) which is a mutagenic natural compound contaminate many
                                                  1
            Email:                            food sources, especially in some parts of Africa and Asia and is
            mosaad_abdelwahhab@ya             recognized as one of the most potent hepatocarcinogens in humans.
            hoo.com                           Recent research pointed out an increasing interest concerning the
                                              health benets of a diet rich in NPs. The use of herbal medicines can be
                                              traced back several thousand years ago in ancient China, ancient
                                              Egyptian and Romans. Generally, NPs have played a key role in drug
                                              discovery and are still a prolic source of novel lead compounds or
                                              pharmacophores for medicinal chemistry. Although, HCC is always
                                              hard to treat, this special issue aims to gather updated progress in this
                                              important area and shed the light on the possibility to introduce a new
                                              drug based on the benet of NPs.



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