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Hiyama et al. Hepatoma Res 2021;7:44 https://dx.doi.org/10.20517/2394-5079.2021.21 Page 11 of 12

Performed data acquisition, as well as provided administrative, technical, and material support: Kurihara S,
Kojima M, Saeki I
Pathological data analysis: Inoue T, Tanaka Y

Availability of data and materials
The datasets are not available for public access due to patient privacy concern enrolled in JPLT-2 trial
because of the risk that will come into conflict with Personal Information Protection Law in Japan.

Financial support and sponsorship
This work was supported by AMED (Academy for Medical Research and Development) (Nos.
20lk0201066h0004 and 20ck0106609h0001).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
This study was performed in accordance with the Declaration of Helsinki and approved by the ethics
committee of Hiroshima University (Hiro-RIN-113). Informed consent to participate in the study was
obtained from the participants, or their parents or legal guardians if under age 16 years.

Consent for publication
Written informed consent was obtained from the patient who underwent surgery.

Copyright
© The Author(s) 2021.

REFERENCES
1. Hubbard AK, Spector LG, Fortuna G, Marcotte EL, Poynter JN. Trends in international incidence of pediatric cancers in children
under 5 years of age: 1988-2012. JNCI Cancer Spectr 2019;3:pkz007. DOI PubMed PMC
2. Aronson DC, Meyers RL. Malignant tumors of the liver in children. Semin Pediatr Surg 2016;25:265-75. DOI PubMed
3. Hiyama E, Hishiki T, Watanabe K, et al. Outcome and late complications of hepatoblastomas treated using the Japanese study group
for pediatric liver tumor 2 protocol. J Clin Oncol 2020;38:2488-98. DOI PubMed
4. Katzenstein HM, Langham MR, Malogolowkin MH, et al. Minimal adjuvant chemotherapy for children with hepatoblastoma resected
at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial. Lancet Oncol 2019;20:719-27. DOI PubMed
PMC
5. Meyers RL, Maibach R, Hiyama E, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's
Hepatic tumors International Collaboration. Lancet Oncol 2017;18:122-31. DOI PubMed PMC
6. Schweinitz D. Hepatoblastoma: recent developments in research and treatment. Semin Pediatr Surg 2012;21:21-30. DOI PubMed
7. Zsiros J, Brugieres L, Brock P, et al. Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma
(SIOPEL-4): a prospective, single-arm, feasibility study. Lancet Oncol 2013;14:834-42. DOI PubMed PMC
8. Fuchs J, Rydzynski J, Von Schweinitz D, et al; Study Committee of the Cooperative Pediatric Liver Tumor Study Hb 94 for the
German Society for Pediatric Oncology and Hematology. Pretreatment prognostic factors and treatment results in children with
hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94. Cancer 2002;95:172-82. DOI PubMed
9. Meyers RL, Tiao G, de Ville de Goyet J, Superina R, Aronson DC. Hepatoblastoma state of the art: pre-treatment extent of disease,
surgical resection guidelines and the role of liver transplantation. Curr Opin Pediatr 2014;26:29-36. DOI PubMed
10. Namgoong JM, Choi JU, Hwang S, Oh SH, Park GC. Pediatric living donor liver transplantation with homograft replacement of
retrohepatic inferior vena cava for advanced hepatoblastoma. Ann Hepatobiliary Pancreat Surg 2019;23:178-82. DOI PubMed PMC
11. Otte JB, Pritchard J, Aronson DC, et al; International Society of Pediatric Oncology (SIOP). Liver transplantation for hepatoblastoma:
results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr
Blood Cancer 2004;42:74-83. DOI PubMed
12. Uchida H, Sakamoto S, Sasaki K, et al. Surgical treatment strategy for advanced hepatoblastoma: resection versus transplantation.
Pediatr Blood Cancer 2018;65:e27383. DOI PubMed
13. Babu BI, Bigam DL, Gilmour SM, Dajani KZ, Shapiro AMJ, Kneteman NM. Liver transplantation in locally unresectable,
undifferentiated embryonal cell sarcoma. Transplant Direct 2021;7:e654. DOI PubMed PMC
14. Meyers RL, Tiao GM, Dunn SP, Langham MR Jr. Liver transplantation in the management of unresectable hepatoblastoma in