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Chávez-López et al. Hepatoma Res 2020;6:14 I http://dx.doi.org/10.20517/2394-5079.2019.023 Page 5 of 16

Table 1. Ion channel expression in major liver diseases
Trans- Genomic Expression
Liver Channel/ Gene Developed name ported mapping change Ref.
disease Transporter symbol ion(s) (chromosome in (compared to
homo sapiens) normal tissue)
Viral p7 -- Hepatitis C virus p7 protein Ca 2+ -- Overexpression [59-61]
hepatitis
SCNN1A SCNN1A Sodium channel non-voltage- Na + 12 Overexpression [55]
gated 1 alpha
+
P2X7 P2RX7 Purinergic receptor P2X, ligand- Na , Ca 2+ 12 Overexpression [56]
gated ion channel 7
+
P2X4 P2RX4 Purinergic receptor P2X, ligand- Na , Ca 2+ 12 Overexpression [72,73]
gated ion channel 4
SOCs ORAI1 Calcium release- activated Ca 2+ 12 Overexpression [51-54]
calcium modulator
GABA Aα1 GABRA1 Gamma-aminobutyric acid type Cl - 5 Overexpression [74]
A receptor alpha 1 subunit
NAFLD K Ca3.1 KCNN4 Calcium-activated potassium K + 19 Overexpression [79,80]
channel subfamily N member 4
+
P2X7 P2RX7 Purinergic receptor P2X, ligand- Na , Ca 2+ 12 Overexpression [81-83]
gated ion channel 7
SOCs -- Store-operated calcium channels Ca 2+ NS Overexpression [8,84]
TPC2 TPCN2 Two-pore segment channel 2 Ca 2+ 11 Overexpression [21,85]
TRPV1 TRPV1 Transient receptor potential Non 17 Overexpression [86,87]
cation channel subfamily V selective
member 1 cation
Fibrosis TRPV4 TRPV4 Transient receptor potential Non- 12 Overexpression [88]
cation channel subfamily V selective
member 4 cation
TRPC6 TRPC6 Transient receptor potential Ca 2+ 11 Overexpression [89]
cation channel subfamily C
member 6
2+
TRPM7 TRPM7 Transient receptor potential Ca , Mg 2+ 15 Overexpression [90]
cation channel subfamily M
member 7
ASIC1a ASIC1 Acid sensing ion channel subunit Na + 12 Overexpression [91]
1
Cirrhosis TRPV2 TRPV2 Transient receptor potential Non- 17 Overexpression [95]
cation channel subfamily V selective
member 2 cation
TRPC6 TRPC6 Transient receptor potential Ca 2+ 11 Overexpression [96]
cation channel subfamily C
member 6
SCN2A Voltage-gated sodium channel Na + 2 Overexpression [96]
Nav 1.2
alpha subunit 2
KCNN4 Calcium-activated potassium K + 19 Overexpression [96]
K Ca3.1
channel subfamily N member 4
ABCC3 ABCC3 ATP binding cassette subfamily C -- 17 Overexpression [96]
member 3
ITPRs ITPR Inositol 1,4,5-trisphosphate Ca 2+ NS Overexpression [97]
receptor
AQP1 AQP1 Aquaporin 1 water 7 Overexpression [98-100]
channel
K Ca1.1 (BK) KCNMA1 Calcium-activated potassium K + 10 Overexpression [21,101]
channel subfamily M alpha 1
+
NCC SLC12A3 Solute carrier family 12 member 3 Na , Cl - 16 Overexpression [102]
HCC K Ca3.1 KCNN4 Calcium-activated potassium K + 19 Overexpression [103,104]
channel subfamily N member 4
KCNQ1 KCNQ1 Voltage-gated potassium channel K + 11 Downregulation [105]
subfamily Q member 1
KCNJ11 KCNJ11 Inwardly rectifying potassium K + 11 Overexpression [106]
channel subfamily J member 1
K ATP channels -- ATP-sensitive potassium K + NS Overexpression [37]
channels
Eag1 KCNH1 Voltage-gated potassium channel K + 1 Overexpression [115]
subfamily H member 1