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Yamaguchi et al. Hepatoma Res 2018;4:50 Hepatoma Research
DOI: 10.20517/2394-5079.2018.68

Review Open Access

Hepatic resection for hepatocellular carcinoma

Shun Yamaguchi , Taichiro Kosaka , Susumu Eguchi
#
#
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 8528102, Japan.
# Authors contributed equally.

Correspondence to: Dr. Susumu Eguchi, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences,
Sakamoto1-7-1, Nagasaki 8528102, Japan. E-mail: sueguchi@nagasaki-u.ac.jp

How to cite this article: Yamaguchi S, Kosaka T, Eguchi S. Hepatic resection for hepatocellular carcinoma. Hepatoma Res
2018;4:50. http://dx.doi.org/10.20517/2394-5079.2018.68

Received: 25 May 2018 First Decision: 16 Jul 2018 Revised: 31 Jul 2018 Accepted: 1 Aug 2018 Published: 22 Aug 2018
Science Editor: Guang-Wen Cao Copy Editor: Jun-Yao Li Production Editor: Cai-Hong Wang

Abstract
Hepatic resection has become the standard treatment of primary liver cancer. Indications for hepatic resection in
patients with hepatocellular carcinoma (HCC) vary greatly between Japan and other countries because the clinical
practice guidelines for HCC defined by the Japan Society of Hepatology differ from the EASL-EORTC clinical practice
guidelines. Hepatic resection is not recommended as a treatment for the patients at Barcelona Clinic Liver Cancer (BCLC)
stage B. Otherwise, there are many surgeons/clinicians who believe that not all HCC patients at BCLC stage B should be
excluded from an indication for hepatectomy because many reports showed good prognosis after hepatic resection for
HCC patients over BCLC stage B. The survival rate is expected to increase with better outcomes of hepatectomy in the
future. This paper has described indications for hepatectomy for patients with HCC through comparison of domestic
guidelines with overseas guidelines, focusing on their differences.

Keywords: Hepatic resection, hepatocellular carcinoma, guidelines

INTRODUCTION
Indications for surgical resection in patients with hepatocellular carcinoma (HCC) vary greatly between
Japan and other countries. This is because many Japanese medical institutions decide on the indication
based on the clinical practice guidelines for HCC defined by the Japan Society of Hepatology , which differs
[1]
from the EASL-EORTC clinical practice guidelines in terms of the HCC stage, and the hepatic reserve
[2]
as an indication for hepatectomy. This paper compares both guidelines in terms of surgical resection for
hepatocellular carcinoma.

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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