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David et al. Hepatoma Res 2018;4:2  I  http://dx.doi.org/10.20517/2394-5079.2017.51                                                    Page 7 of 8


               One of the major limitations of this study is its retrospective nature and small sample size with difference
               in basic characteristics in both groups. However, our 5-year OS rate of 60% and 44% for LLR and OLR,
               respectively, is satisfactory, and may justify the expansion of indications for surgical resection in the case of
               multiple, large HCC, if the liver functions remains at Child-Pugh class A.

               In conclusion, this retrospective study demonstrates that LLR and OLR have comparable OS and DFS rates
               for BCLC-B HCC patients with multiple or large tumors. Particularly, decreased postoperative complications
               and shorter hospital stay, with successful achievement of adequate resection margins, was observed in the
               LLR group. It was demonstrated that good oncologic and perioperative outcomes can be achieved with LLR
               for HCC.


               DECLARATIONS
               Authors’ contributions
               Collecting and analyzing data, writing the manuscript: David A
               Design this study, analyzing data, finalizing the manuscript: Choi YR
               Analyzing data and drafting the manuscript: Han HS, Yoon YS, Cho JY

               Data source and availability
               Data and survey materials are available upon request from the corresponding author.

               Financial support and sponsorship
               None.

               Conflicts of interest
               There are no conflicts of interest.

               Patient consent
               Agreement exemption allowed by the Institutional Review Board (IRB) of Seoul National University
               Bundang Hospital (SNUBH).

               Ethics approval
               This retrospective, observational study was approved by the Institutional Review Board (IRB) of Seoul
               National University BundangHospital (SNUBH, B-1801-442-108).


               Copyright
               © The Author(s) 2018.



               REFERENCE
               1.   National Comprehensive Cancer Network. Clinical practice guidelines in oncology: hepatobiliary cancers. Version 4.2017.
               2.   Lee JJ, Conneely JB, Smoot RL, Gallinger S, Greig PD, Moulton CA, Wei A, McGilvray I, Cleary SP. Laparoscopic vs open liver resection
                   for hepatocellular carcinoma at a North American Center: a 2-to-1 matched pair analysis. HPB (Oxford) 2015;17:304-10.
               3.   Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020-2.
               4.   Garancini M, Pinotti E, Nespoli S, Romano F, Gianotti L, Giardini V. Hepatic resection beyond barcelona clinic liver cancer indication;
                   when and how. World J Hepatol 2016;8:513-19.
               5.   Cipriani F, Fantini C, Ratti F, Lauro R, Tranchart H, Halls M, Scuderi V, Barkhatov L, Edwin B, Troisi RI, Dagher I, Reggiani P, Belli G,
                   Aldrighetti L, Abu Hilal M. Laparoscopic liver resections for hepatocellular carcinoma: can we extend the surgical indication in cirrhotic
                   patients? Surg Endosc 2017; doi: 10.1007/s00464-017-5711-x.
               6.   Mussin N, Sumo M, Lee KW, Choi YR, Choi JY, Ahn SW, Yoon KC, Kim HS, Hong SK, Yi NJ, Suh KS. The correlation between
                   preoperative volumetry and real graft weight: comparison of two volumetry programs. Ann Surg Treat Res 2017;92:214-20.
               7.   Nugroho A, Kim OK, Lee KW, Song S, Kim H, Hong SK, Yoon KC, Kim HS, Choi YR, Lee HW, Yi NJ, Suh KS. Evaluation of donor
                   workups and exclusions in a single-center experience of living donor liver transplantation. Liver Transpl 2017;23:614-24.
               8.   Han KH, Kudo M, Ye SL, Choi JY, Poon RT, Seong J, Park JW, Ichida T, Chung JW, Chow P, Cheng AL. Asian consensus workshop report:
                   expert consensus guidelines for the management of intermediate and advanced hepatocellular carcinoma in Asia. Oncology 2011;81:158-64.
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