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David et al. Hepatoma Res 2018;4:2 I http://dx.doi.org/10.20517/2394-5079.2017.51 Page 7 of 8

One of the major limitations of this study is its retrospective nature and small sample size with difference
in basic characteristics in both groups. However, our 5-year OS rate of 60% and 44% for LLR and OLR,
respectively, is satisfactory, and may justify the expansion of indications for surgical resection in the case of
multiple, large HCC, if the liver functions remains at Child-Pugh class A.

In conclusion, this retrospective study demonstrates that LLR and OLR have comparable OS and DFS rates
for BCLC-B HCC patients with multiple or large tumors. Particularly, decreased postoperative complications
and shorter hospital stay, with successful achievement of adequate resection margins, was observed in the
LLR group. It was demonstrated that good oncologic and perioperative outcomes can be achieved with LLR
for HCC.

DECLARATIONS
Authors’ contributions
Collecting and analyzing data, writing the manuscript: David A
Design this study, analyzing data, finalizing the manuscript: Choi YR
Analyzing data and drafting the manuscript: Han HS, Yoon YS, Cho JY

Data source and availability
Data and survey materials are available upon request from the corresponding author.

Financial support and sponsorship
None.

Conflicts of interest
There are no conflicts of interest.

Patient consent
Agreement exemption allowed by the Institutional Review Board (IRB) of Seoul National University
Bundang Hospital (SNUBH).

Ethics approval
This retrospective, observational study was approved by the Institutional Review Board (IRB) of Seoul
National University BundangHospital (SNUBH, B-1801-442-108).

Copyright
© The Author(s) 2018.

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