Page 209 - Read Online

Ohtsuka et al. Hepatoma Res 2024;10:18 https://dx.doi.org/10.20517/2394-5079.2024.04 Page 5 of 6

Figure 4. The course of the replaced left hepatic artery (R-LHA) and a lymph node (LN) near the liver along the replaced left hepatic
artery (R-LHA).

The prognostic impact of LND along the left embryonic (aberrant) hepatic artery also remains unknown.
Few reports have focused on the survival benefit of gastrohepatic LND. Igami et al. showed that the survival
of the patients with gastrohepatic LNM was dismal, with no 2-year survivors among 7 patients with
gastrohepatic LNM . In contrast, in our own practice, the median survival of 11 patients with LNM along
[20]
the left embryonic (aberrant) hepatic artery was 32 months, with four surviving more than 3 years
[Supplementary Table 1]. However, because the number of cases was quite small in both experiences, the
significance of LND along the left embryonic (aberrant) hepatic artery could not be interpreted accurately.
Further large-scale studies are needed.

SUMMARY
Predominant lymphatic spread from the ICC in the left-sided liver might be closely related to the course of
the artery to the left-sided liver: the LHA and the LEHA. These hypotheses should be confirmed by further
analyses using a large number of cases.

DECLARATIONS
Authors’ Contributions
Made substantial contributions to the conception and design of the study and collecting material and
writing the manuscript: Ohtsuka M, Takayashiki T, Takano S, Suzuki D, Sakai N, Hosokawa I, Mishima T,
Konishi T, Suzuki K, Nishino H, Nakada S

Availability of Data and Materials
Not applicable.

Financial Support and Sponsorship
None.

Conflicts of Interest
All authors declared that there are no conflicts of interest.

Ethical Approval and Consent to Participate
Not applicable.

Consent for Publication
Not applicable.