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Figure 2. Clinical decision algorithm for repeated TACE in HCC. TACE: Transarterial chemoembolization; HCC: hepatocellular carcinoma;
mRECIST: modified Response Evaluation Criteria in Solid Tumors; ALBI: albumin-bilirubin grade; CP: Child-Pugh score; CR: complete
response; PR: partial response; SD: stable disease; PD: progressive disease.
survival benefit; (2) local and systemic synergy: TACE serves as a locoregional modality, while targeted
therapy plus immunotherapy act systemically. Their combination not only enhances tumor remission rates
