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Ribovski et al. Extracell Vesicles Circ Nucleic Acids 2023;4:283-305 https://dx.doi.org/10.20517/evcna.2023.26 Page 5

Figure 1. EV biogenesis and cellular processing. EV endocytosis, intracellular trafficking, and cargo release may result in phenotypic
changes in recipient cells. It remains to be established if, within MVBs, there is a mixed presence of newly-formed ILVs and internalized
EVs (mixture hypothesis) or that MVBs contain either ILVs or EVs (segregation hypothesis). This image was created with BioRender (
https://biorender.com/).

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not alter the uptake of these EVs exposed to the same cell types in the absence of electrical stimulation .
We should mention that the authors did not evaluate EV uptake by cells that were stimulated by electricity;