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Special Issue introduction:

Chiral compounds are widely found in numerous pharmaceuticals, functional

materials, chiral catalysts and chiral ligands. Consequently, the synthesis of chiral
compounds has become an important goal in the community of chemistry, medicinal
chemistry and materials science. Among various approaches, asymmetric catalysis,
for which the 2001 Nobel Prize in Chemistry was awarded, has been demonstrated
to be the most efficient method for accessing chiral compounds. Asymmetric

catalysis mainly includes metal catalysis, enzyme catalysis and organocatalysis.
Particularly, asymmetric organocatalysis was the research area recognized by
the Nobel Prize in chemistry in 2021. Undoubtedly, asymmetric organocatalysis

has unique advantages such as easy preparation and high stability of chiral
organocatalysts, mild and environment-friendly reaction conditions, and avoiding
transition-metal contamination in the chiral products, especially in pharmaceuticals.
As a result, due to the advantages of asymmetric organocatalysis in synthesizing
enantioenriched molecules with potential bioactivity, developing organocatalytic

asymmetric reactions and discovering their applications in the asymmetric synthesis
of optically pure molecules have been and will continue to be a long-lasting topic
in the research field of asymmetric organocatalysis. This Special Issue focuses

on the applications and future prospects of asymmetric organocatalysis, which is
dedicated to Changzhou University on the occasion of her 45th anniversary in 2023.
More importantly, this Special Issue will showcase and highlight the latest findings
in the field of asymmetric organocatalysis and other related research fields, which
will inspire chemists worldwide to prompt future development and applications of

asymmetric organocatalysis.

Specific areas to be covered include, but are not limited to:

● Development of organocatalytic asymmetric reactions
● Organocatalytic asymmetric synthesis of chiral molecules
● Application of chiral molecules as organocatalysts
● Asymmetric organocatalysis-directed catalyst design
● Theoretical investigation on asymmetric organocatalysis

● Cooperative or relay catalysis involving organocatalysis
● Applications of organocatalysis in industrial synthesis
● New routes for the synthesis of chiral organocatalysts

● Asymmetric organocatalysis in medicinal chemistry
● Asymmetric organocatalysis with polymeric materials