Page 36 - Read Online
P. 36

Conroy et al. Cancer Drug Resist 2021;4:543-58  https://dx.doi.org/10.20517/cdr.2021.07  Page 13

               Availability of data and materials
               Not applicable.


               Financial support and sponsorship
               Funding source: Work in Walter Kolch’s lab is funded by Science Foundation Ireland (SFI) under Grant
               Numbers 18/SPP/3522 and 14/IA/2395.

               Conflicts of interest
               All authors declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2021.


               REFERENCES
               1.       Harvey JJ. An unidentified virus which causes the rapid production of tumours in mice. Nature 1964;204:1104-5.  DOI  PubMed
               2.       Kirsten WH, Mayer LA. Morphologic responses to a murine erythroblastosis virus. J Natl Cancer Inst 1967;39:311-35.  PubMed
               3.       Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
                   Science 2008;321:1801-6.  DOI  PubMed  PMC
               4.       Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov
                   2014;13:828-51.  DOI  PubMed  PMC
               5.       Kwong LN, Davies MA. Targeted therapy for melanoma: rational combinatorial approaches. Oncogene 2014;33:1-9.  DOI  PubMed
               6.       Polivka J Jr, Janku F. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther 2014;142:164-75.  DOI
                   PubMed
               7.       Cromm PM, Spiegel J, Grossmann TN, Waldmann H. Direct Modulation of Small GTPase Activity and Function. Angew Chem Int Ed
                   Engl 2015;54:13516-37.  DOI  PubMed
               8.       Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 2008;9:517-31.  DOI  PubMed  PMC
               9.       Colicelli J. Human RAS superfamily proteins and related GTPases. Sci STKE 2004;2004:RE13.  DOI  PubMed  PMC
               10.      Weinberg RA. The biology of cancer. 2nd ed. New York, NY: Garland Science; 2014.
               11.      Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 2011;11:761-74.  DOI
                   PubMed  PMC
               12.      Coelho MA, de Carné Trécesson S, Rana S, et al. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1
                   mRNA. Immunity 2017;47:1083-1099.e6.  DOI  PubMed  PMC
               13.      Tuveson DA, Shaw AT, Willis NA, et al. Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and
                   developmental defects. Cancer Cell 2004;5:375-87.  DOI  PubMed
               14.      Guerra C, Mijimolle N, Dhawahir A, et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
                   Cancer Cell 2003;4:111-20.  DOI  PubMed
               15.      Murugan AK, Grieco M, Tsuchida N. RAS mutations in human cancers: Roles in precision medicine. Semin Cancer Biol 2019;59:23-
                   35.  DOI  PubMed
               16.      Mengoli MC, Barbieri F, Bertolini F, Tiseo M, Rossi G. K-RAS mutations indicating primary resistance to crizotinib in ALK-
                   rearranged adenocarcinomas of the lung: Report of two cases and review of the literature. Lung Cancer 2016;93:55-8.  DOI  PubMed
               17.      Martinelli E, Morgillo F, Troiani T, Ciardiello F. Cancer resistance to therapies against the EGFR-RAS-RAF pathway: The role of
                   MEK. Cancer Treat Rev 2017;53:61-9.  DOI  PubMed
               18.      Marks JL, Broderick S, Zhou Q, et al. Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung
                   adenocarcinoma. J Thorac Oncol 2008;3:111-6.  DOI  PubMed
               19.      Cadranel J, Mauguen A, Faller M, et al. Impact of systematic EGFR and KRAS mutation evaluation on progression-free survival and
                   overall survival in patients with advanced non-small-cell lung cancer treated by erlotinib in a French prospective cohort (ERMETIC
                   project--part 2). J Thorac Oncol 2012;7:1490-502.  DOI  PubMed
               20.      Berndt N, Hamilton AD, Sebti SM. Targeting protein prenylation for cancer therapy. Nat Rev Cancer 2011;11:775-91.  DOI  PubMed
                   PMC
               21.      Morgillo F, Lee HY. Lonafarnib in cancer therapy. Expert Opin Investig Drugs 2006;15:709-19.  DOI  PubMed
   31   32   33   34   35   36   37   38   39   40   41