Page 25 - Read Online

Fabbrizi et al. Cancer Drug Resist 2020;3:775-90 I http://dx.doi.org/10.20517/cdr.2020.49 Page 787

6. National Cancer Registration & Analysis Service and Cancer Research UK. Chemotherapy, Radiotherapy and Surgical Tumour
Resections in England. Availabe from: http://www.ncin.org.uk/cancer_type_and_topic_specific_work/topic_specific_work/main_cancer_
treatments. [Last accessed on 9 Sep 2020]
7. Kim JK, Leeman JE, Riaz N, McBride S, Tsai CJ, et al. Proton therapy for head and neck cancer. Curr Treat Options Oncol 2018;19:28.
8. Stanisce L, Koshkareva Y, Xu Q, Patel A, Squillante C, et al. Stereotactic body radiotherapy treatment for recurrent, previously irradiated
head and neck cancer. Technol Cancer Res Treat 2018;17:1533033818780086.
9. Castelli J, Simon A, Lafond C, Perichon N, Rigaud B, et al. Adaptive radiotherapy for head and neck cancer. Acta Oncol 2018;57:1284-92.
10. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009;461:1071-8.
11. Ranjha L, Howard SM, Cejka P. Main steps in DNA double-strand break repair: an introduction to homologous recombination and related
processes. Chromosoma 2018;127:187-214.
12. Pannunzio NR, Watanabe G, Lieber MR. Nonhomologous DNA end-joining for repair of DNA double-strand breaks. J Biol Chem
2018;293:10512-23.
13. Mao Z, Bozzella M, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell
cycle in human cells. Cell Cycle 2008;7:2902-6.
14. Goodhead DT. Energy deposition stochastics and track structure: what about the target? Radiat Prot Dosimetry 2006;122:3-15.
15. Hill MA. Radiation track structure: how the spatial distribution of energy deposition drives biological response. Clin Oncol (R Coll
Radiol) 2020;32:75-83.
16. Loeffler JS, Durante M. Charged particle therapy--optimization, challenges and future directions. Nat Rev Clin Oncol 2013;10:411-24.
17. Vitti ET, Kacperek A, Parsons JL. Targeting DNA double-strand break repair enhances radiosensitivity of HPV-positive and HPV-negative
head and neck squamous cell carcinoma to photons and protons. Cancers (Basel) 2020;12.
18. Carter RJ, Nickson CM, Thompson JM, Kacperek A, Hill MA, et al. Complex DNA damage induced by high linear energy transfer alpha-
particles and protons triggers a specific cellular DNA damage response. Int J Radiat Oncol Biol Phys 2018;100:776-84.
19. Carter RJ, Parsons JL. Base excision repair, a pathway regulated by posttranslational modifications. Mol Cell Biol 2016;36:1426-37.
20. Edmonds MJ, Parsons JL. Regulation of base excision repair proteins by ubiquitylation. Exp Cell Res 2014;329:132-8.
21. Carter RJ, Nickson CM, Thompson JM, Kacperek A, Hill MA, et al. Characterisation of deubiquitylating enzymes in the cellular response
to high-LET ionizing radiation and complex DNA damage. Int J Radiat Oncol Biol Phys 2019;104:656-65.
22. Berman TA, Schiller JT. Human papillomavirus in cervical cancer and oropharyngeal cancer: one cause, two diseases. Cancer
2017;123:2219-29.
23. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N
Engl J Med 2010;363:24-35.
24. Rieckmann T, Tribius S, Grob TJ, Meyer F, Busch CJ, et al. HNSCC cell lines positive for HPV and p16 possess higher cellular
radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol 2013;107:242-6.
25. Nickson CM, Moori P, Carter RJ, Rubbi CP, Parsons JL. Misregulation of DNA damage repair pathways in HPV-positive head and neck
squamous cell carcinoma contributes to cellular radiosensitivity. Oncotarget 2017;8:29963-75.
26. Weaver AN, Cooper TS, Rodriguez M, Trummell HQ, Bonner JA, et al. DNA double strand break repair defect and sensitivity to poly
ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma. Oncotarget
2015;6:26995-7007.
27. Dok R, Bamps M, Glorieux M, Zhao P, Sablina A, et al. Radiosensitization approaches for HPV-positive and HPV-negative head and
neck squamous carcinomas. Int J Cancer 2020;146:1075-85.
28. Ruttkay-Nedecky B, Jimenez Jimenez AM, Nejdl L, Chudobova D, Gumulec J, et al. Relevance of infection with human papillomavirus:
the role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review). Int J Oncol 2013;43:1754-62.
29. Prigge ES, Arbyn M, von Knebel Doeberitz M, Reuschenbach M. Diagnostic accuracy of p16(INK4a) immunohistochemistry in
oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis. Int J Cancer 2017;140:1186-98.
30. Dok R, Kalev P, Van Limbergen EJ, Asbagh LA, Vazquez I, et al. p16INK4a impairs homologous recombination-mediated DNA repair in
human papillomavirus-positive head and neck tumors. Cancer Res 2014;74:1739-51.
31. Wang L, Zhang P, Molkentine DP, Chen C, Molkentine JM, et al. TRIP12 as a mediator of human papillomavirus/p16-related radiation
enhancement effects. Oncogene 2017;36:820-8.
32. Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC. The concentration of oxygen dissolved in tissues at the time of irradiation as a
factor in radiotherapy. Br J Radiol 1953;26:638-48.
33. Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J
Cancer 1955;9:539-49.
34. Evans SM, Du KL, Chalian AA, Mick R, Zhang PJ, et al. Patterns and levels of hypoxia in head and neck squamous cell carcinomas and
their relationship to patient outcome. Int J Radiat Oncol Biol Phys 2007;69:1024-31.
35. Becker A, Hansgen G, Bloching M, Weigel C, Lautenschlager C, et al. Oxygenation of squamous cell carcinoma of the head and neck:
comparison of primary tumors, neck node metastases, and normal tissue. Int J Radiat Oncol Biol Phys 1998;42:35-41.
36. Ivan M, Kondo K, Yang H, Kim W, Valiando J, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation:
implications for O2 sensing. Science 2001;292:464-8.
37. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by
O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
38. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, et al. The tumour suppressor protein VHL targets hypoxia-inducible