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Zhang et al. Cancer Drug Resist 2024;7:30 Cancer
DOI: 10.20517/cdr.2024.62
Drug Resistance

Review Open Access

The role of circRNAs and miRNAs in drug resistance
and targeted therapy responses in breast cancer

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1
1
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Meilan Zhang , Zhaokuan Zheng , Shouliang Wang , Ruihan Liu , Mengli Zhang , Zhiyun Guo , Hao Wang ,
Weige Tan 3
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The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou 511400, Guangdong, China.
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Department of Orthopedics, Affiliated Huadu Hospital, Southern Medical University (People’s Hospital of HuaduDistrict),
Guangzhou 510810, Guangdong, China.
3
Department of Breast Surgery, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong,
China.
Correspondence to: Prof. Zhiyun Guo, Prof. Hao Wang, The Affiliated Panyu Centra Hospital of Guangzhou Medical University,
No. 8, Fuyu East Road, Qiaonan Street, Panyu District, Guangzhou 511400, Guangdong, China. E-mail: zhiyun2005@126.com;
pyblk@hotmail.com; Prof. Weige Tan, Department of Breast Surgery, the First Affiliated Hospital, Guangzhou Medical University,
No. 151, Yanjiang West Road, Yuexiu District, Guangzhou 510120, Guangdong, China. E-mail: tanweige@gzhmu.edu.cn
How to cite this article: Zhang M, Zheng Z, Wang S, Liu R, Zhang M, Guo Z, Wang H, Tan W. The role of circRNAs and miRNAs
in drug resistance and targeted therapy responses in breast cancer. Cancer Drug Resist 2024;7:30. https://dx.doi.org/10.20517/
cdr.2024.62
Received: 16 May 2024 First Decision: 4 Jul 2024 Revised: 20 Jul 2024 Accepted: 2 Aug 2024 Published: 20 Aug 2024

Academic Editors: Mario Cioce, Hailin Tang Copy Editor: Dong-Li Li Production Editor: Dong-Li Li

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs comprising 19-24 nucleotides that indirectly control gene
expression. In contrast to other non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are defined by their
covalently closed loops, forming covalent bonds between the 3’ and 5’ ends. circRNAs regulate gene expression by
interacting with miRNAs at transcriptional or post-transcriptional levels. Accordingly, circRNAs and miRNAs
control many biological events related to cancer, including cell proliferation, metabolism, cell cycle, and apoptosis.
Both circRNAs and miRNAs are involved in the pathogenesis of diseases, such as breast cancer. This review
focuses on the latest discoveries on dysregulated circRNAs and miRNAs related to breast cancer, highlighting their
potential as biomarkers for clinical diagnosis, prognosis, and chemotherapy response.

Keywords: miRNAs, circRNAs, breast cancer, clinical values

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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