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Page 174 Genovese et al. Cancer Drug Resist 2018;1:164-80 I http://dx.doi.org/10.20517/cdr.2018.10

Sorcin is overexpressed in MD-resistant cancer cells, co-amplified with ABCB1, ABCB4 and other
proteins involved in the resistance to chemotherapy in cancer cells. Sorcin overexpression induces
resistance to many different chemotherapeutic drugs, while Sorcin silencing reverts drug resistance, by
acting on many pathways.

Sorcin is therefore an important MDR marker and may represent a therapeutic target for reversing MDR.

DECLARATIONS
Acknowledgments
We acknowledge “Quality methods for Design of Experiments in Scientific Research”, in the FaReBio di
Qualità Project: Quality and Project Management OpenLab: qPMO CNR; the Flagship Project Nanomax:
“NADINE: Nanotechnology-based Diagnostics In Neurological diseases and Experimental oncology”; PRIN
20154JRJPP MIUR; Progetto Ricerca Finalizzata Min. Salute RF-2016-02364123 RAREST‐JHD.

Authors’ contributions
Conception of the work: Ilari A, Colotti G
Draft and revision of the work: Genovese I, Ilari A, Battista T, Chiarini V, Fazi F, Fiorillo A, Colotti G

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2018.

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