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                          Table 1. Main table describing study characteristics

                                                                                    Mean                                         Comparison                                         Neural
                          Paper      Dataset details       Imaging Model details absolute       Correlation   Accuracy metrics with other          Key            Validation        network        Batch  No. of
                                                                                                                                                                                                   size
                                                                                                                                                                                                           epochs
                                                                                                                                                   limitations
                                                                                                                                                                  approach
                                                                                                coefficient
                                                                                    error                                        methods                                            architecture
                          Chae et al.  Training - 400;     X-ray    Decentralized   1.45°-3.52° NA           Mean absolute error:  Compared to     Requires       40 test           Custom         NA      Initial:
                               [18]
                          2020       resolution - 3,240 ×           CNN; multiple                            1.45°-3.52° for     manual            multiple ordered  radiographs;   decentralized          0.001,
                                     1,080 pixels; variety -        orders                                   parameters          measurement by    datasets,      comparison to     CNN                    SGDM
                                     57% normal spine,                                                                           experienced       training time;   manual                                 momentum
                                     20% lumbar lordosis,                                                                        surgeons, as well  limited diversity measurements by                      0.95
                                     24% thoracic kyphosis                                                                       as regression                    experienced
                                                                                                                                 CNN model                        surgeons
                          Wu et al.   526 (154 patients);   X-ray   Custom MVC-     Landmark:  NA            Mean absolute error  Compared to      Single clinic   10-fold patient-  Custom MVC- 100       Starting:
                               [19]
                          2018       resolution: 128 × 256          Net             0.0398-                  (landmark): 0.0398  manual            dataset; no    wise cross-       Net                    0.01, halved
                                     pixels                                         0.0459;                  (AP) - 0.0459       measurement and  metal artifact   validation;                             every 10
                                                                                    Cobb:                    (LAT); circular mean  other deep      images         comparison to                            epochs
                                                                                    4.04°-                   absolute error (Cobb  learning methods               manual “gold
                                                                                    4.07°                    angle): 4.04° (AP) -                                 standard”
                                                                                                             4.07° (LAT)
                          Wang et    526; resolution:      X-ray    Custom MVE-     Cobb:       NA           Circular mean       Compared to       Single clinic   Used same        Custom MVE- NA         Starting:
                                 [20]
                          al. 2019   0.26 mm/pixel                  Net             6.26°-7.81°              absolute error (Cobb  manual          dataset        dataset as        Net                    0.01
                                                                                                             angle): 7.81° (AP) -   measurement and               previous study;
                                                                                                             6.26° (LAT); SMAPE  other deep                       compared to other
                                                                                                             (Cobb angle):       learning methods                 deep learning
                                                                                                             24.94% (AP) -                                        methods
                                                                                                             11.90% (LAT)

                          Zhang et   2,738 pairs (AP & LAT  X-ray   Custom MPF-     Landmark:  NA            Scaled mean         Compared to       Single clinic   10-fold cross-   Custom MPF- 120        Initial:
                                 [21]
                          al. 2022   X-rays); from local            Net             0.0046-                  absolute error      manual            dataset        validation;       Net                    0.001,
                                     hospital                                       0.0050;                  (landmark): 0.0046  measurement and                  comparison to                            decayed by
                                                                                    Cobb:                    (AP) - 0.0050       other deep                       manual “gold                             0.2 every 30
                                                                                    3.52°-4.05°              (LAT); circular mean  learning methods               standard”                                epochs
                                                                                                             absolute error (Cobb                                 measurements
                                                                                                             angle): 3.52° (AP) -
                                                                                                             4.05° (LAT); SMAPE
                                                                                                             (Cobb angle):
                                                                                                             13.71% (AP) -
                                                                                                             12.60% (LAT)
                          Zerouali   100 patients with     X-ray    SmartXpert      ≤ 2.9° or ≤  ≥ 0.85 except  Mean absolute error:  Compared to   Mainly pediatric  Comparison to   NA           NA      NA
                          et al.     coronal & sagittal             (Milvue)        2.7 mm      thoracic     ≤ 2.9° or ≤ 2.7 mm   measurements by  population,    “gold standard”
                               [22]
                          2023       whole spine                                                kyphosis =   for parameters;     senior            exclusions     manual
                                     radiographs                                                0.58         intraclass correlation  musculoskeletal   restricted   measurements;
                                                                                                             coefficient: ≥ 0.85   radiologist     analysis to    visual assessment
                                                                                                             except thoracic     (ground truth)    preoperative   of reliability by
                                                                                                             kyphosis = 0.58                       patients       radiologists
                          Korez et   145 images to train   X-ray    RetinaNet + U-  1.2°-5.0°   NA           Mean absolute       Compared to       Single center   Statistical analysis  RetinaNet + U- NA  NA
                                 [23]
                          al. 2020   model, 97 test images          Net CNNs                                 difference vs. manual  manual         data; did not   (mean absolute   Net
                                     with variety of                                                         measurements: 1.2°- measurements by  evaluate intra-  difference,
                                     conditions                                                              5.0° for parameters  spine surgeon    observer       correlation
   81   82   83   84   85   86   87   88   89   90   91