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Skoreński et al. Rare Dis Orphan Drugs J 2023;2:6 Rare Disease and
DOI: 10.20517/rdodj.2022.21
Orphan Drugs Journal

Review Open Access

Neutrophil serine proteases

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Marcin Skoreński , Karolina Torzyk , Marcin Sieńczyk
Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology,
Wroclaw 50-370, Poland.
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These authors contributed equally to this work.
Correspondence to: Dr. Marcin Sieńczyk, Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw
University of Science and Technology, Wybrzeze Wyspianskiego 27, Wroclaw 50-370, Poland.
E-mail: marcin.sienczyk@pwr.edu.pl

How to cite this article: Skoreński M, Torzyk K, Sieńczyk M. Neutrophil serine proteases. Rare Dis Orphan Drugs J 2023;2:6.
https://dx.doi.org/10.20517/rdodj.2022.21

Received: 4 Nov 2022 First Decision: 15 Feb 2023 Revised: 9 Mar 2023 Accepted: 20 Mar 2023 Published: 28 Mar 2023

Academic Editors: Daniel Scherman, Brice Korkmaz Copy Editor: Ying Han Production Editor: Ying Han

Abstract
The identification and characterization of the four active neutrophil serine proteases (NSPs) have provided a better
understanding of their roles in various physiological and pathological processes. The availability of appropriate
tools such as substrates, inhibitors, and activity-based probes (ABPs) for studying their activity and functions in
cells has become increasingly important. In this paper, the authors provide a comprehensive overview of the
current knowledge on the tools available for studying NSPs. The substrates, inhibitors, and ABPs developed to date
are described, including their strengths and limitations. The authors also discuss the potential implications of these
tools for future research on NSPs, including their potential use in the development of new therapeutics for various
diseases. Overall, this paper highlights the importance of understanding the activity and functions of NSPs and
provides valuable information on the tools available for studying these proteases.

Keywords: Neutrophils, neutrophil serine proteases (NSPs), substrates, inhibitors, activity-based probes (ABPs)

INTRODUCTION
Neutrophils are the most abundant group of leukocytes normally occurring in human blood, which play an
essential role in the innate branch of the immune system. The main functions of this type of cell are to fight
[1]
infections and promote an inflammatory response to the onset of diseases caused by bacteria or fungi .

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0
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