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Hsu. Vessel Plus 2022;6:18 https://dx.doi.org/10.20517/2574-1209.2021.117 Page 3 of 5

management of stroke; (2) novel measures of similarity and asymmetry in upper limb activities for
identifying hemiparetic severity in stroke survivors; (3) 7T MRI quantification of brain glutamate in acute
ischemic stroke; (4) artificial intelligence decision support system to manage acute stroke; and (5) using
disruptive technologies to transform pre-hospital care of stroke. Finally, Prof. Bruce Campbell, the 6th
leader from Australia, Head of Stroke and Interim Head of Neurology at the Royal Melbourne Hospital, is
also a professorial fellow in the Melbourne Brain Centre, an honorary professorial fellow at The Florey
Institute of Neuroscience and Mental Health, and a fellow of the Australian Academy of Health and
Medical Science. His research interest has been focused on the imaging and treatment of acute stroke. Prof.
Campbell was a co-principal investigator and medical coordinator of the EXTEND-IA and EXTEND-IA
TNK multi-center randomized trials on thrombectomy with trial results published in the New England
[5]
Journal of Medicine in 2015 and 2018 . He is the Chair of Clinical Council, a Director of the Stroke
Foundation, and Co-Chair of the Australian stroke “living” guidelines working party. He has been an
inaugural member of the Victorian stroke telemedicine project and chairs the Victorian Statewide Stroke
Reperfusion Therapy Committee. He also co-chairs the World Stroke Organization Young Stroke
Professionals Committee and is the coordinator of the National Brainschool training program for
neurologists in training.

In total, 6 of the 10 articles in this special issue of Vessel Plus on stroke, are authored by world-renowned
stroke investigators from Australia, reflecting the robust clinical research activities on stroke in Australia in
recent years.

The other global leaders on stroke research who have each contributed an article are Prof. Jin-Moo Lee,
Prof. Adnan Qureshi, Prof. Kazunori Toyoda, and Prof. Shinn-Zong Lin, Prof. Jin-Moo Lee, the Norman J.
Stupp Professor of Neurology at Hope Center, Washington University, is the Director of the Stroke Center
at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, Missouri, USA
which has been ranked the number one stroke center in the United States by HealthGrades in 2001. In July
2021, Prof. Lee has been promoted to be Head of the Department of Neurology with a more prestigious
endowed professorship, Andrew B. and Gretchen P. Jones Professor. Prof. Adnan Qureshi is a renowned
international leader on stroke research. The widely applied Qureshi Grading System for angiographic
evaluation of arterial occlusion and recanalization response to intra-arterial thrombolysis in the setting of
acute ischemic stroke has been highly valuable in clinical practice during the evaluation and management of
patients with acute ischemic stroke. Prof. Adnan Qureshi has also been the global principal investigator in a
multinational clinical trial, ATACH II, which was sponsored by NINDS to explore the safety and efficacy of
intense blood pressure regulation in improving the functional outcome of patients with intracranial
hemorrhage in the acute setting. This multinational trial has had a major impact on clinical practice in
treating patients with intracerebral hemorrhage. The key ATACH II trial results were published in the
[6]
New England Journal of Medicine with a series of follow-up publications in other high-impact journals
such as Lancet Neurology, Neurology, Stroke, International Journal of Stroke, and other journals. Prof.
Kazunori Toyoda, the Deputy Director General of the Hospital at the National Cerebral and Cardiovascular
Center in Suita, Japan, has been directing a group of stroke investigators in Japan to join multicenter stroke
trials including a number of landmark global trials in the development of better therapeutic measures for
stroke. Prof. Kazunori Toyoda’s group has published stroke trial results extensively in high-impact journals
including New England Journal of Medicine, Lancet, Circulation, Annals of Neurology, and others. Prof.
Shinn-Zong Lin, Professor of Neurosurgery and Superintendent of Tzu Chi Medical Center in Hualien,
Taiwan, is a pioneer in applying stem cells to treat stroke. Prof. Shinn-Zong Lin was the first investigator in
the world to show that stem cell therapy was able to restore lost neurological function in patients with
chronic stroke.