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Page 12 of 22 Strassheim et al. Vessel Plus 2018;2:29 I http://dx.doi.org/10.20517/2574-1209.2018.44

CONCLUSION
Research has highlighted many examples of pathological GPCR signaling, which can be targets for novel
PH therapeutics. In PH pre-clinical studies many targets have been identified, but only few are druggable
[Tables 1 and 2]. GPCRs, by contrast, represent good targets for pharmacological strategies and in all likeli-
hood present one of the best opportunities for therapeutic intervention in PH. The heart alone is estimated
to express some 200 different GPCRs, suggesting significantly better therapeutics based on targeting GP-
CRs are possible. The challenge is to devise the best pharmacological cocktail for the PH patient. At the
moment, while much has been published with respect to GPCR action in PH, much more clearly awaits
discovery.

DECLARATIONS
Authors’ contributions
Literature review: Strassheim D
Writing the manuscript: Strassheim D, Karoor V, Gerasimovskaya E
Organizing the manuscript: Karoor V
Experimental data presented in the manuscript: Stenmark K
Discussion of the manuscript: Verin A, Gerasimovskaya E
Material support: Gerasimovskaya E

Availability of data and materials
Not applicable.

Financial support and sponsorship
The study was supported by grants from National Institute of Health R01-HL-086783 (to Gerasimovskaya E).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2018.

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