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Browne et al. Vessel Plus 2024;8:19 https://dx.doi.org/10.20517/2574-1209.2023.126 Page 7 of 18

Table 3. Summary of trials published before and after 2018 that evaluated patency of saphenous vein, radial artery and RIMA grafts
Conduit - n/N (%)
Study Year Saphenous Radial Patency Design Time of imaging CABG
(years)
surgery type
definition
vein artery RIMA
[73]
Gaudino et al. 2005 - 1/40 (2.5) 2/40 occlusion SC 4.3 On-pump
(AVGSRS) (5.0)
[18]
Alexander et al. 2005 1,198/4,537 - - occlusion MC 1 On/off-pump
(PREVENT IV) (26.4)
[22]
Collins et al. 2008 6/44 (13.6) 1/59 (1.7) - occlusion SC 5 On-pump
(RSVP)
[15]
Kulik et al. 2010 6/90 (6.7) - - occlusion MC 1 On/off-pump
(CASCADE)
Hayward et al. [32] 2010 7/112 (6.3) 8/311 (2.6) 10/196 occlusion SC 5.5 On/off-pump
(RAPCO) (5.1)
Goldman et al. [74] 2011 30/269 (11.2) 28/266 - occlusion MC 1 On/off-pump
(VACSP) (10.5)
Glineur et al. [75] 2011 5/81 (6.2) - 8/37 occlusion SC 3 On/off-pump
(21.6)
Mannacio et al. [76] 2012 35/267 (13.1) 1/52 (1.9) 1/63 (1.6) occlusion SC 1 On/off-pump
(CRYSSA)
Deb et al. [21] 2012 50/269 (18.6) 24/269 (8.9) - occlusion MC 7.7 On/off-pump
(RAPS)
[25]
Song et al. 2012 4/59 (6.8) 2/71 (2.8) - occlusion SC 1 Off-pump
[77]
Hattler et al. 2012 513/2,603 - - occlusion MC 1 On/off-pump
(ROOBY) (19.7)*
Dreifaldt et al. [78] 2013 2/52 (3.8) 8/58 (13.8) - occlusion SC 3 On-pump
[79]
Houlind et al. 2014 140/694 (20.2) 44/176 9/36 > 50% or MC 0.5 On/off-pump
(DOORS) (25.0) (25.0) occlusion
Subtotal: 1,996/9,077 117/1,302 30/372
(22.0) (9.0) (8.1)
[16]
Zhao et al. (DACAB) 2018 211/1,460 - - occlusion MC 1 On/off-pump
(14.5)*
[80]
Kim et al. (SAVE 2018 10/214 (4.7) - 4/173 occlusion SC 5 Off-pump
RITA) (2.3)
[14]
Kulik et al. (ACTIVE) 2019 30/247 (12.1) - - occlusion MC 1 On/off-pump
[6]
Lamy et al. (COMPASS 2019 221/2,292 (9.6) 8/93 (8.6) 18/84 occlusion MC 1 On/off-pump
CABG) (21.4)
[17]
Willemsen et al. 2020 94/954 (9.9) - - occlusion MC 1 On/off-pump
(POPular CABG)
[39]
Tian et al. 2021 214/4,224 - - occlusion MC 1 On/off-pump
(5.1)*
[19]
Kulik et al. (TARGET) 2021 52/338 (15.4) - - occlusion MC 1 On/off-pump
Subtotal: 832/9,729 (8.6 8/93 (8.6) 22/257
(8.6)
Overall: 2,822/18,716 >125/1,395 52/629
95%CI: (15.1) (9.0) (8.3)
14.6-15.6 7.6-10.6 6.4-10.7
*Rates of graft occlusion were significantly different among treatment groups (overall occlusion rate reported). CI: Confidence interval; LIMA: left
internal mammary artery; MC: multi-centre; RIMA: right internal mammary artery; SC: single-centre.

received skeletonized rather than pedicled IMA). A meta-analysis of 5 studies, which included 1,988 patients
and 1,764 grafts, found that the odds of failure was numerically higher in skeletonized compared with
pedicled grafts, but this difference was not significant (odds ratio 1.35; 95%CI: 0.41-4.47) .
[35]