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Elhage et al. Plast Aesthet Res 2020;7:16 I http://dx.doi.org/10.20517/2347-9264.2020.03 Page 3 of 9

Timing of injections At least 4 weeks prior to surgery At least 4 weeks prior to surgery 0-9 days prior to surgery (median 6 days) 2 weeks prior to surgery 1-2 weeks prior to surgery 4 weeks prior to surgery 2-4 weeks prior to surgery 4 weeks prior to surgery 3-4 weeks prior to surgery 4-6 weeks prior to surgery

Injection sites 6 total, 3 sites bilaterally at EO, IO, and TA, 50 U/25 mL per site (16.6 units/8.3 mL per muscle) 6 total, 3 sites bilaterally at EO, IO, and TA, 50 U/25 mL per site (8 mL per muscle) 10 total, 5 sites bilaterally, 16.6 U/5 mL per site, divided between EO, IO, and TA* 6 total, 3 sites bilaterally at EO, IO, and TA, or 6 total, 3 sites bilerally at EO and IO 10 total, 5 sites bilaterally, 16.6 U/5 mL per site, divided between EO, IO, an

10 total, 5 sites bilaterally, 16.6 units per site* 10 total, 5 sites bilaterally between EO and IO, 16.6 U/5 mL per site* 6 total, 3 sites bilaterally at EO, IO, and TA 6 total, 3 sites bilaterally at EO and IO commonly published conversion ratio of 1:3 onabotulinum toxin A:abobotulinum toxin A to report the total BTA units used in each study [25] . Ibarra-Hurtado et al. [14,16] injected between the EO and IO in their 2013 study and did not spec

Table 1. Summary of botulinum toxin A treatment regimens

Total BTA units 166 units* 166 units* 300 units 300 units 200-300 units 166 units* 200 units 166 units* 300 units 200-300 units units of onabotulinum toxin A (Botox®) corresponds to the 500 units of abobotulinum toxin A (Dysport®) used in these studies

n 12 17 22 8 56 70 46 80 37 12

Year 2009 2014 2013 2016 2018 2018 2020 2019 2020 2020

Ibarra-Hurtado et al. [14] Ibarra-Hurtado et al. [16] Zendejas et al. [17] Farooque et al. [18] Rodriguez-Acevedo et al. [19] Bueno-Lledó et al. [20] Elstner et al. [22] Bueno-Lledó et al. [21] Nielsen et al. [23] RESULTS Botulinum toxin A regimens Botulinum toxin A efficacy recurrences.

Ref. Chan et al. [24]