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Page 8 of 18                                Stoneburner et al. Plast Aesthet Res 2020;7:13  I  http://dx.doi.org/10.20517/2347-9264.2019.028

               Table 2. Indications for surgery
               Indications for surgery     No. of articles    No. of extremities  Percentage of extremities (%)
               Osteomyelitis                   9
               Nonunion                        3                   85                       58.2
               Acute trauma (+/- infection)    9                   61                       41.8
               Total articles                  14                  146


               Table 3. Surgical approach
               Surgical approach                 No. of articles  No. of extremities  Percentage of extremities (%)
               Flap first                            9                83                     56.8
               Simultaneous application of flap and frame  7          54                     37.0
               Frame first                           4                9                      6.2
               Total articles                        14               146

               Table 4. Type of flap
               Type of flap                    No. of articles  No. of extremities  Percentage of extremities (%)
               Rectus abdominis                     9                47                     40.9
               Free latissimus dorsi                12               42                     36.5
               Rotational gastrocnemius             4                11                     9.6
               Reverse sural                        2                3                      2.6
               Soleus                               1                3                      2.6
               Radial forearm flow-through          2                2                      1.7
               Rotational latissimus dorsi*         2                2                      1.7
               Cross leg                            2                2                      1.7
               Serratus                             1                1                      0.9
               Gracilis                             1                1                      0.9
               Combined LD + serratus               1                1                      0.9
               Total articles                       13               115
               *Used for upper extremity reconstruction. LD: latissimus dorsi


               underwent simultaneous application of frame and soft tissue flap (37.0%) while others had the application
               of a flap first (56.8%) or frame first (6.2%) [Table 3]. With respect to soft tissue reconstruction, four of the
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               14 articles quantified the soft tissue defect. The average soft tissue defect was 125 cm  (range of 88-219 cm ).
               All 14 articles discussed the general type(s) of flaps used. Soft tissue reconstruction was most commonly
               performed with free flaps (88.0%) as opposed to rotational flaps (12.0%). Of these, most were muscle
               flaps (96.7%) with fewer being fasciocutaneous flaps (3.3%). However, only 13 of the 14 articles specified
               the type of flap used for each procedure. The most frequently used flaps were free latissimus dorsi and
               rectus abdominis, followed by rotational gastrocnemius [Table 4]. Seven of the 14 articles discussed type
               of anastomosis. End-to-side anastomosis (55.2%) was performed slightly more often than end-to-end
               anastomosis (44.8%), and, while a large range of recipient vessels was used, posterior tibial (53.2%) and
               anterior tibial (24.2%) were the most common [Table 5].

               With regard to bone reconstruction and transport, bone defect was mentioned in nine articles, whereas total
               length of distraction was mentioned in four of the 14 articles. The average bone defect was 8.9 cm (range
               of 6.0-12.5 cm) and average total distraction was 6.1 cm (range of 4.3-10 cm). The time to distraction was
               discussed in five of the 14 articles, and rate of distraction was discussed in six of the 14 articles. The average
               time to distraction was 24.1 days (range of 7-73.5 days) and the average rate of distraction was 0.96 mm/day
               (range of 0.75-1 mm/day).

               As discussed in 11 of the 14 articles, additional techniques were utilized for some extremities. These
               techniques included bone graft (62.3%), antibiotic beads (48.6%), antibiotic bone substitute (13.0%), vein
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