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Kayiran et al. Plast Aesthet Res 2018;5:9 I http://dx.doi.org/10.20517/2347-9264.2017.86 Page 7 of 8

to reprogram differentiated fibroblasts into an embryonic stem cell state [38,39] . A recent study exhibits the
creation of a bioengineered hair follicle germ using embryonic skin-derived epithelium and mesenchymal
donor cells where the transplanted germ integrate to the host epithelium producing a complete functional
hair . A recent study revealed the generation of folliculogenic human epithelial stem cells from induced
[40]
[41]
pluripotent stem cells . The regenerated hair follicles possed a KRT15+ stem cell population and produced
hair shafts expressing hair specific keratins. These results suggest an approach for generating large numbers
of human epithelial stem cells for tissue engineering and new treatments for hair loss, wound healing and
other degenerative skin disorders.

Forthcoming studies will ensure better results. As the technology contributes to the medicine, it is possible
that the whole process will be carried out entirely with robotic and automated systems. Indeed, the future
may give the solutions by solely cell-based applications enabling hair growth without a surgery. Up-to-date,
I believe that the combination of the surgical methods with the help of additional options may give the best
option for the patients to re-gain their natural-looking hair with adequate density.

DECLARATIONS
Authors’ contributions
Concept, design, resource, data collection and processing, and manuscript writing: Kayiran O, Cihandide E
Supervision, literature search, analysis and interpretation: Kayiran O

Data source and availability
Data in this study were derived from searches of the PubMed database.

Financial support and sponsorship
None.

Conflicts of interest
There are no conflicts of interest.

Patient consent
Consents from all of the patients were established prior to submission.

Ethics approval
Local Committee of Ethics approved this study with SAH-17-214.

Copyright
© The Author(s) 2018.

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