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Figure 4. Graft on 1st dressing on day 5 (Patient S. No. 1)
Figure 5. Autologous platelet rich plasma being injected into the residual raw area on day 5 following debridement of dead graft (Patient S. No. 1)
DISCUSSION
Skin grafts survival occurs via serum imbibition, direct vessel to vessel re-anastomosis (inosculation),
and neovascularization. Neovascularization is defined by ingrowth of new vessels from the recipient site
into the graft.
APRP as contains a high concentration of alpha granules, is an easy and a very cost-effective approach
to obtaining high concentrations of these growth factors. These alpha granules of platelets are known
to contain growth factors such as PDGF, vascular endothelial growth factor, TGF, EGF, which promote
[7]
angiogenesis, cell proliferation, maturation, and matrix formation as described above .
The application of APRP results in prompt tissue regeneration and a reduced risk of infection, pain, and loss
[8]
of blood. El-Sharkawy et al. in their study have suggested that platelet rich plasma also suppresses cytokine
[9]
release, thus limiting inflammation, and promoting tissue regeneration. Pallua et al. have reported
